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GAB2 (GRB2-associated-binding protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Myeloproliferative neoplasms and Chronic myeloid leukaemia.
Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signalling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signalling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation.
Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.84, animal model 0.41, genetic association 0.47).
In plain words · GAB2 (GRB2-associated-binding protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Myeloproliferative neoplasms and Chronic myeloid leukaemia.
GAB2 (GRB2-associated-binding protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Myeloproliferative neoplasms and Chronic myeloid leukaemia.
Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signalling pathways.
No product in this corpus aims at GAB2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1998. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1998, "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". Source.
Sources: HGNC HGNC:14458 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UQC2 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000033327 (association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: chronic myelogenous leukaemia, BCR-ABL1 positive 0.54, myeloproliferative neoplasm 0.59, leukaemia 0.59 (GraphQL API, CC0))
Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signalling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signalling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and haematopoiesis. Location: Cytoplasm; Cell membrane; Membrane raft (UniProt). Locus 11q14.1 (HGNC).
Query for this target: (TITLE:"GAB2" OR ABSTRACT:"GAB2" OR TITLE:"GRB2 associated binding protein 2" OR ABSTRACT:"GRB2 associated binding protein 2" OR TITLE:"GRB2-associated-binding protein 2" OR ABSTRACT:"GRB2-associated-binding protein 2" OR TITLE:"KIAA0571" OR ABSTRACT:"KIAA0571") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GAB2, not a curated reading list.
Shares BCR::ABL1 (Philadelphia chromosome), Chronic myeloid leukaemia (KEGG map), Chronic myeloid leukaemia (CML), Myeloproliferative neoplasms (PV, ET, myelofibrosis).
Shares Chronic myeloid leukaemia (CML), Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Open Targets Platform.
Shares Chronic myeloid leukaemia (CML), Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Open Targets Platform.
Shares Chronic myeloid leukaemia (CML), Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Open Targets Platform.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Open Targets Platform.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Open Targets Platform.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Open Targets Platform.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Open Targets Platform.