{"entity":{"id":"gab2","kind":"target","name":"GAB2","aka":["GRB2 associated binding protein 2","GRB2-associated-binding protein 2","KIAA0571"],"tldr":"GAB2 (GRB2-associated-binding protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Myeloproliferative neoplasms and Chronic myeloid leukaemia.","summary":"Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signalling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signalling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation.\n\nOpen Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.84, animal model 0.41, genetic association 0.47).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:14458","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14458"},{"label":"UniProt Q9UQC2","url":"https://www.uniprot.org/uniprotkb/Q9UQC2/entry"},{"label":"NCBI Gene 9846","url":"https://www.ncbi.nlm.nih.gov/gene/9846"},{"label":"Ensembl ENSG00000033327","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000033327"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["leukaemia","myeloproliferative-neoplasms","cml"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["bcr-abl1-signalling","cml-signalling"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"GAB2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:14458","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14458","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UQC2","url":"https://www.uniprot.org/uniprotkb/Q9UQC2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000033327","url":"https://platform.opentargets.org/target/ENSG00000033327/associations","note":"association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: chronic myelogenous leukaemia, BCR-ABL1 positive 0.54, myeloproliferative neoplasm 0.59, leukaemia 0.59 (GraphQL API, CC0)"}],"specificitySources":[],"hgnc":"HGNC:14458","ensembl":"ENSG00000033327","uniprot":"Q9UQC2","entrez":"9846","firstDescribed":1998,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1998, \"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/9628581/","biology":"Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signalling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signalling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and haematopoiesis. Location: Cytoplasm; Cell membrane; Membrane raft (UniProt). Locus 11q14.1 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.59 with leukaemia (MONDO_0005059)","Myeloproliferative neoplasms: Open Targets association 0.59 with myeloproliferative neoplasm (MONDO_0020076)","Chronic myeloid leukaemia: Open Targets association 0.54 with chronic myelogenous leukaemia, BCR-ABL1 positive (MONDO_0011996)"],"targetClass":"other","prevalence":[]},"route":"/targets/gab2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"cml","kind":"cancer","name":"Chronic myeloid leukaemia (CML)","route":"/cancers/cml/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"}],"pathway":[{"id":"bcr-abl1-signalling","kind":"pathway","name":"BCR::ABL1 (Philadelphia chromosome)","route":"/pathways/bcr-abl1-signalling/"},{"id":"cml-signalling","kind":"pathway","name":"Chronic myeloid leukaemia (KEGG map)","route":"/pathways/cml-signalling/"}]}}