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ELP1 (Elongator complex protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Medulloblastoma.
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyses the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation.
In plain words · ELP1 (Elongator complex protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Medulloblastoma.
ELP1 (Elongator complex protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Medulloblastoma.
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).
No product in this corpus aims at ELP1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1998. Earliest sequence paper UniProt cites for the protein: Cohen et al, Nature, 1998, "IKAP is a scaffold protein of the IkappaB kinase complex". Source.
Sources: HGNC HGNC:5959 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O95163 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000070061 (per-cancer scores at or above 0.5: medulloblastoma 0.72 (GraphQL API, CC0))
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyses the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA. May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK). Location: Cytoplasm; Nucleus (UniProt). Locus 9q31.3 (HGNC).
Query for this target: (TITLE:"ELP1" OR ABSTRACT:"ELP1" OR TITLE:"elongator acetyltransferase complex subunit 1" OR ABSTRACT:"elongator acetyltransferase complex subunit 1" OR TITLE:"Elongator complex protein 1" OR ABSTRACT:"Elongator complex protein 1" OR TITLE:"TOT1" OR ABSTRACT:"TOT1" OR TITLE:"IKI3" OR ABSTRACT:"IKI3" OR TITLE:"IKBKAP" OR ABSTRACT:"IKBKAP") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ELP1, not a curated reading list.
Shares Medulloblastoma, Open Targets Platform.
Shares Medulloblastoma, Open Targets Platform.
Shares Medulloblastoma, Open Targets Platform.
Shares Medulloblastoma, Open Targets Platform.
Shares Medulloblastoma, Open Targets Platform.
Shares Medulloblastoma, Open Targets Platform.
Shares Medulloblastoma, Open Targets Platform.
Shares Medulloblastoma, Open Targets Platform.