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Ubamatamab (REGN4018) is Regeneron's investigational MUC16×CD3 bispecific antibody, in phase 1/2 and phase 2 trials for ovarian and endometrial cancer.
Ubamatamab (REGN4018) is a bispecific antibody that binds MUC16 on tumour cells and CD3 on T cells and is designed to redirect T-cell killing towards MUC16-expressing cells. The first-in-human study NCT03564340 tests ubamatamab alone or with cemiplimab in recurrent ovarian cancer and other MUC16-positive cancers (phase 1/2); NCT06787612 is a multi-arm phase 2 platform study of ubamatamab combinations in platinum-resistant ovarian cancer; NCT04590326 combines it with the MUC16×CD28 costimulatory bispecific REGN5668; and NCT07154290 tests it with marlotamig in non-small-cell lung cancer. No results are recorded here; the registry entries and the cited abstracts are the sources.
Bispecific antibody that binds MUC16 on tumour cells and CD3 on T cells, bringing them together to promote T-cell-mediated killing of MUC16-expressing cells. Connects to MUC16 (CA-125) and CD3.
1.One arm of Ubamatamab binds MUC16 (CA-125) on the cancer cell.
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance: how tumours escape each drug class · Lines of therapy.
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Query for this drug: (TITLE:"Ubamatamab" OR ABSTRACT:"Ubamatamab" OR TITLE:"REGN4018" OR ABSTRACT:"REGN4018") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Ubamatamab, not a curated reading list.
Shares MUC16 (CA-125), Ovarian cancer and the tag pipeline.
Shares CD3, T-cell engagers (bispecific), Ovarian cancer and the tag pipeline.
Shares Endometrial cancer, Ovarian cancer and the tag pipeline.
Shares Endometrial cancer, Ovarian cancer and the tag pipeline.
Shares Endometrial cancer, Ovarian cancer and the tag pipeline.
Shares Endometrial cancer, Ovarian cancer and the tag pipeline.
Shares Endometrial cancer, Ovarian cancer and the tag pipeline.
Shares Endometrial cancer, Ovarian cancer and the tag pipeline.