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Trials
Dual-Targeting CAR-NK Cells for Recurrent Ovarian Cancer (MSLN, FRα, MUC16)

trialsTrialRecruiting

Dual-Targeting CAR-NK Cells for Recurrent Ovarian Cancer (MSLN, FRα, MUC16)

A phase 1/2 trial of Dual-target CAR-NK cell product in ovarian cancer, run by Beijing Biotech, now recruiting.

Overview Connected5

Overview

Dual-Targeting CAR-NK Cells for Recurrent Ovarian Cancer (MSLN, FRα, MUC16) is a phase 1/2 interventional study registered as NCT07480954 by Beijing Biotech, with 36 participants planned, started 2026-02-04 and due to reach its primary completion in 2027-02-17. Interventions recorded: Dual-target CAR-NK cell product and Lymphodepleting chemotherapy.

Setting

A Phase 1/2, Open-Label, Biomarker-Assigned Study of Dual-Targeting CAR-NK Cells Directed Against Mesothelin (MSLN), Folate Receptor Alpha (FRα/FOLR1), and/or MUC16 (CA125) in Patients With Recurrent or Refractory High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Phase

Phase 1/2

Sponsor

Beijing Biotech

Registry

Started

2026-02-04

Enrolled

36 enrolled

Connected

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cancers

High-grade serous ovarian cancer Ovarian cancer

targets

Folate receptor alpha Mesothelin MUC16 (CA-125)

Evidence strength16/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
36 enrolled+8
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Link 1,018 registry trials to cancer subtype pages by dri… · diff · file

Sources & links

ClinicalTrials.gov NCT07480954

Data

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Cancers

Ovarian cancer
High-grade serous ovarian cancer

Targets

Folate receptor alpha
Mesothelin
MUC16 (CA-125)

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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