{"entity":{"id":"nct07480954","kind":"trial","name":"Dual-Targeting CAR-NK Cells for Recurrent Ovarian Cancer (MSLN, FRα, MUC16)","aka":[],"tldr":"A phase 1/2 trial of Dual-target CAR-NK cell product in ovarian cancer, run by Beijing Biotech, now recruiting.","summary":"Dual-Targeting CAR-NK Cells for Recurrent Ovarian Cancer (MSLN, FRα, MUC16) is a phase 1/2 interventional study registered as NCT07480954 by Beijing Biotech, with 36 participants planned, started 2026-02-04 and due to reach its primary completion in 2027-02-17. Interventions recorded: Dual-target CAR-NK cell product and Lymphodepleting chemotherapy.","status":"recruiting","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT07480954","url":"https://clinicaltrials.gov/study/NCT07480954"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["ovarian","high-grade-serous-ovarian-cancer"],"sections":[],"technologies":[],"targets":["folr1","mesothelin","muc16"],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07480954","phase":"1/2","setting":"A Phase 1/2, Open-Label, Biomarker-Assigned Study of Dual-Targeting CAR-NK Cells Directed Against Mesothelin (MSLN), Folate Receptor Alpha (FRα/FOLR1), and/or MUC16 (CA125) in Patients With Recurrent or Refractory High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancer","sponsor":"Beijing Biotech","started":"2026-02-04","startedType":"actual","enrolled":36,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07480954/","neighbours":{"cancer":[{"id":"high-grade-serous-ovarian-cancer","kind":"cancer","name":"High-grade serous ovarian cancer","route":"/cancers/high-grade-serous-ovarian-cancer/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}],"target":[{"id":"folr1","kind":"target","name":"Folate receptor alpha","route":"/targets/folr1/"},{"id":"mesothelin","kind":"target","name":"Mesothelin","route":"/targets/mesothelin/"},{"id":"muc16","kind":"target","name":"MUC16 (CA-125)","route":"/targets/muc16/"}]}}