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Trials
A Study to Investigate Ubamatamab With and Without Marlotamig (REGN7075) in Adult Participants With Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)

trialsTrialRecruiting

A Study to Investigate Ubamatamab With and Without Marlotamig (REGN7075) in Adult Participants With Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)

A phase 2 trial of Ubamatamab and REGN7075 in non-small-cell lung cancer, run by Regeneron Pharmaceuticals, now recruiting.

Overview Connected5

Overview

A Study to Investigate Ubamatamab With and Without Marlotamig (REGN7075) in Adult Participants With Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC) is a phase 2 interventional study registered as NCT07154290 by Regeneron Pharmaceuticals, with 300 participants planned, started 2026-03-18 and due to reach its primary completion in 2030-06-10. Interventions recorded: Ubamatamab, Marlotamig and Sarilumab.

Setting

A Phase 2 Study to Investigate Ubamatamab With and Without Marlotamig (REGN7075) in Treatment-Experienced Participants With Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)

Phase

Phase 2

Sponsor

Regeneron Pharmaceuticals

Registry

Started

2026-03-18

Enrolled

300 enrolled

Connected

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cancers

Non-small-cell lung cancer

technologies

T-cell engagers (bispecific)

drugs

Phase 2Bispecific antibody

Phase 2Bispecific T-cell engager (MUC16×CD3)

companies

Evidence strength27/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 2+15
300 enrolled+12
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT07154290

Data

JSON ·

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Cancers

Non-small-cell lung cancer

Technologies

T-cell engagers (bispecific)

Products

Ubamatamab
REGN7075

Companies

Regeneron

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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