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Rindopepimut is a peptide vaccine against EGFRvIII, a mutant protein found only on some glioblastomas. After a phase 2 that beat historical controls, the 745-patient double-blind phase 3 ACT IV found no benefit in 2016, and tumours in both arms had lost EGFRvIII at recurrence, a lesson in antigen escape.
EGFRvIII peptide conjugated to KLH with GM-CSF. Phase 2 (ACT III) suggested prolonged survival versus historical controls; the double-blind phase 3 ACT IV (n=745, EGFRvIII-positive newly diagnosed glioblastoma with minimal residual disease) showed no OS benefit (20.1 vs 20.0 months). Loss of EGFRvIII expression at recurrence in both arms illustrated antigen escape. Celldex discontinued the programme.
Induces humoral and cellular immunity against the EGFRvIII neoepitope. Connects to EGFR.
1.Rindopepimut slips into a pocket on EGFR.
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance: how tumours escape each drug class · Lines of therapy.
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Query for this drug: (TITLE:"Rindopepimut" OR ABSTRACT:"Rindopepimut" OR TITLE:"CDX-110" OR ABSTRACT:"CDX-110") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Rindopepimut, not a curated reading list.
Shares Off-the-shelf cancer vaccines, Glioma & glioblastoma.
Shares Off-the-shelf cancer vaccines, Glioma & glioblastoma.
Shares EGFRvIII, The brain: barrier and sanctuary, EGFR, Glioma & glioblastoma.
Shares Off-the-shelf cancer vaccines, Glioma & glioblastoma.
Shares The brain: barrier and sanctuary, Glioma & glioblastoma.
Shares Off-the-shelf cancer vaccines, Glioma & glioblastoma.
Shares Off-the-shelf cancer vaccines, EGFR.
Shares The brain: barrier and sanctuary, Glioma & glioblastoma.