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Envafolimab is the first PD-L1 antibody given as a quick injection under the skin rather than an infusion, approved in China for advanced tumours with mismatch-repair deficiency.
Approved by the NMPA in November 2021 for previously treated MSI-H or dMMR advanced solid tumours, on a single-arm study across colorectal and other cancers, the first subcutaneous PD-(L)1 antibody approved anywhere. Developed by Alphamab Oncology with 3D Medicines in China; TRACON Pharmaceuticals held North American rights for a sarcoma programme that did not succeed. Its convenience rather than potency is the point: a 30-second injection in a country where infusion chairs are scarce outside big cities.
Backbone ribbon from PDB 5JDS. RCSB PDB 5JDS. The ribbon widens where the chain is folded into a regular pattern and narrows where it is a loose loop.
Envafolimab is this nanobody fused to an Fc; the Fc is not shown.
Camelid-derived humanised single-domain anti-PD-L1 antibody fused to an IgG1 Fc, small enough for a rapid subcutaneous injection. Connects to PD-L1.
1.Envafolimab binds PD-L1.
Compare all products across the US, EU, UK, Japan, China and Australia →
| Region | Year | Indication |
|---|---|---|
| China | 2021 | Previously treated MSI-H or dMMR advanced solid tumours |
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Query for this drug: (TITLE:"Envafolimab" OR ABSTRACT:"Envafolimab" OR TITLE:"Enweida" OR ABSTRACT:"Enweida" OR TITLE:"KN035" OR ABSTRACT:"KN035") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Envafolimab, not a curated reading list.
Shares PD-1 / PD-L1 immune checkpoint & T-cell activation, PD-L1, Monoclonal antibodies, Immune checkpoint inhibitors and the tag china.
Shares PD-1 / PD-L1 immune checkpoint & T-cell activation, PD-L1, Monoclonal antibodies, Immune checkpoint inhibitors and the tag china.
Shares Monoclonal antibodies and the tag china.
Shares Immune checkpoint inhibitors and the tag china.
Shares PD-1 / PD-L1 immune checkpoint & T-cell activation, Monoclonal antibodies, Immune checkpoint inhibitors and the tag china.
Shares Immune checkpoint inhibitors and the tag china.
Shares Immune checkpoint inhibitors and the tag china.
Shares Immune checkpoint inhibitors and the tag china.