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Carotuximab was an antibody against endoglin, a protein on growing blood vessels and on angiosarcoma cells. Added to pazopanib in the phase 3 TAPPAS trial it did not help, and the trial was stopped in 2019.
Carotuximab (TRC105) was Tracon Pharmaceuticals' antibody against endoglin, a marker of angiogenic endothelium and of angiosarcoma, a cancer that arises from blood vessel lining. Endoglin signalling was thought to be one way tumours escape VEGF blockade, so the antibody was combined with VEGFR inhibitors. Early-phase results in angiosarcoma with pazopanib were encouraging.
The randomised phase 3 TAPPAS trial of pazopanib with or without carotuximab in advanced angiosarcoma was stopped in 2019 after an interim analysis showed no improvement in progression-free survival, and the programme ended. The angiosarcoma page lists it with bevacizumab added to paclitaxel (ANGIOTAX-PLUS) among the antiangiogenic additions that failed.
Binds endoglin (CD105), a TGF-beta co-receptor highly expressed on proliferating tumour endothelium and on angiosarcoma cells, to block a vessel-growth pathway that escapes VEGF inhibition.
1.Carotuximab binds its target.
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance: how tumours escape each drug class · Lines of therapy.
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Query for this drug: (TITLE:"Carotuximab" OR ABSTRACT:"Carotuximab" OR TITLE:"TRC105" OR ABSTRACT:"TRC105") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Carotuximab, not a curated reading list.
Shares Pazopanib and the tag subtype-drugs-wave.
Shares Monoclonal antibodies and the tag subtype-drugs-wave.
Shares Monoclonal antibodies and the tag subtype-drugs-wave.
Shares TAPPAS, Angiosarcoma.
Shares TAPPAS, Pazopanib, Angiosarcoma.
Shares Pazopanib, Angiosarcoma.