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10x Genomics
Leader in single-cell and spatial biology tools (Chromium, Visium, Xenium) used to dissect tumours.
Overview
10x Genomics, based in Pleasanton, California, and listed as TXG, is the leader in single-cell and spatial biology tools, with Chromium for single-cell RNA and ATAC sequencing, Visium HD for spatial transcriptomics and Xenium for in situ analysis. Its instruments are core to tumour microenvironment research and to the atlases from which cell-state models are built. OnCo links it to single-cell and spatial profiling and spatial biology instruments, to bottlenecks on cold tumours and tumour heterogeneity, and to ideas such as mapping which tumour clones sit next to which immune cells before choosing therapy and setting standards for spatial biomarkers before they reach the clinic. Whether spatial biology moves from research tool to clinical test is the open question. The technology pages carry the detail.
Similar pages
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- TechnologySpatial transcriptomics
Shares Spatial transcriptomics platforms (Visium HD, Xenium, MERFISH, CosMx, CODEX), Spatial biology instruments, Single-cell & spatial profiling.
- CollectionCZ CELLxGENE / Human Cell Atlas
Shares Single-cell RNA sequencing (scRNA-seq, 10x Chromium), Single-cell & spatial profiling, Cold tumours and the immunosuppressive microenvironment.
- IdeaFind the parts of a tumour the drug never reaches
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- IdeaA national rapid research autopsy network for end-stage cancer
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- IdeaBlock the survival signals the tumour's neighbours provide
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- TermTumour-infiltrating lymphocytes (TILs)
Shares Map which tumour clones sit next to which immune cells before choosing therapy, Standards for spatial and multiplex tissue biomarkers before they reach the clinic, Spatial-omics-guided treatment selection, Turn the map of immune cells inside a tumour into a standardised test.
- IdeaClear the suppressive neutrophils out of pancreatic tumours first
Shares Single-cell & spatial profiling, Cold tumours and the immunosuppressive microenvironment.
fronts
technologies
terms
ideas
An open model of every cancer cell state, built from perturbation atlasesMap which tumour clones sit next to which immune cells before choosing therapyStandards for spatial and multiplex tissue biomarkers before they reach the clinicTurn the map of immune cells inside a tumour into a standardised test