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New imaging shows where every cell type sits in a tumour slice. Using it to see which sub-populations are hidden from immune cells could explain why immunotherapy fails in parts of a tumour.
Spatial transcriptomics and multiplex imaging can now assign genotype-inferred clones and immune phenotypes to positions in a section. The proposal is a diagnostic-biopsy pipeline reporting clone-immune neighbourhoods: which subclones are immune-excluded, which express MHC, and whether resistant clones cluster in immune deserts. This would be used to decide whether to combine a targeted agent with immunotherapy or a stroma-modifying agent.
Shares 10x Genomics, Tumour-infiltrating lymphocytes (TILs), Single-cell & spatial profiling, Hot vs cold tumours.
Shares 10x Genomics, Tumour-infiltrating lymphocytes (TILs), Single-cell & spatial profiling, Hot vs cold tumours.
Shares 10x Genomics, Tumour-infiltrating lymphocytes (TILs), Single-cell & spatial profiling, Hot vs cold tumours.
Shares Single-cell & spatial profiling, Hot vs cold tumours, Digital pathology & AI, No one can predict who responds to immunotherapy.
Shares 10x Genomics, Single-cell & spatial profiling, Tumour heterogeneity and clonal evolution.
Shares Tumour-infiltrating lymphocytes (TILs), Single-cell & spatial profiling, Hot vs cold tumours, No one can predict who responds to immunotherapy.
Shares Tumour-infiltrating lymphocytes (TILs), Hot vs cold tumours, No one can predict who responds to immunotherapy.
Shares Single-cell & spatial profiling, Hot vs cold tumours.