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Whether immune cells are next to cancer cells matters more than how many there are. Turning that spatial picture into a reliable, standardised test would predict response better.
Spatial features such as the distance from cytotoxic T cells to tumour cells, the presence of immune-excluded phenotypes and B-cell aggregates outperform PD-L1 and tumour mutational burden in retrospective series. No spatial assay has been standardised as a companion diagnostic, and platform variability, staining variability and analytical drift are unaddressed. Reference tissue standards and a locked analysis pipeline are the prerequisites.
Shares 10x Genomics, Tumour-infiltrating lymphocytes (TILs), Single-cell & spatial profiling, Hot vs cold tumours.
Shares BostonGene, 10x Genomics, Tumour-infiltrating lymphocytes (TILs), Pathology & radiology foundation models.
Shares 10x Genomics, Tumour-infiltrating lymphocytes (TILs), Single-cell & spatial profiling, Hot vs cold tumours.
Shares Estimation of the Percentage of US Patients With Cancer Who Are Eligible for and Respond to Checkpoint Inhibitor Immunotherapy Drugs, Single-cell & spatial profiling, Hot vs cold tumours, Digital pathology & AI.
Shares Tumour proportion score (TPS), Estimation of the Percentage of US Patients With Cancer Who Are Eligible for and Respond to Checkpoint Inhibitor Immunotherapy Drugs, Pathology & radiology foundation models, Single-cell & spatial profiling.
Shares Estimation of the Percentage of US Patients With Cancer Who Are Eligible for and Respond to Checkpoint Inhibitor Immunotherapy Drugs, Tumour-infiltrating lymphocytes (TILs), Single-cell & spatial profiling, Hot vs cold tumours.
Shares Lunit, Paige AI, Pathology & radiology foundation models, AI that is built but not validated or deployed.
Shares Paige AI, Pathology & radiology foundation models, AI that is built but not validated or deployed, Digital pathology & AI.