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Trials
Dual-Target MSLN/FAP CAR-NK Cells for Pleural and Peritoneal Mesothelioma

trialsTrialRecruiting

Dual-Target MSLN/FAP CAR-NK Cells for Pleural and Peritoneal Mesothelioma

A phase 1/2 trial of EB-MF-CAR-NK-01, Fludarabine, Cyclophosphamide in mesothelioma, run by Beijing Biotech, now recruiting.

Overview Connected6

Overview

Dual-Target MSLN/FAP CAR-NK Cells for Pleural and Peritoneal Mesothelioma is a phase 1/2 interventional study registered as NCT07510815 by Beijing Biotech, with 36 participants planned, started 2026-03-02 and due to reach its primary completion in 2027-03-14. Interventions recorded: EB-MF-CAR-NK-01, Fludarabine, Cyclophosphamide. Conditions listed: Malignant Pleural Mesotheliomas. No results are recorded here; the registry entry is the source.

Setting

A Phase 1/2, Open-Label, Nonrandomized, Biomarker-Guided Study of Locoregional Allogeneic Dual-Target Mesothelin (MSLN) / Fibroblast Activation Protein (FAP) Chimeric Antigen Receptor Natural Killer Cells in Adults With Unresectable, Recurrent, or Refractory Pleural or Peritoneal Mesothelioma

Phase

Phase 1/2

Sponsor

Beijing Biotech

Registry

Started

2026-03-02

Enrolled

36 enrolled

Connected

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cancers

Mesothelioma Peritoneal mesothelioma Pleural mesothelioma

drugs

ApprovedAlkylating agent (oxazaphosphorine prodrug)

Cyclophosphamide · Cytoxan / Endoxan

Phase 2bispecific antibody

EB-MF-CAR-NK-01

ApprovedPurine nucleotide analogue (antimetabolite)

Fludarabine · Fludara (historic)

Evidence strength21/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
36 enrolled+8
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Link 1,018 registry trials to cancer subtype pages by dri… · diff · file

Sources & links

ClinicalTrials.gov NCT07510815

Data

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Cancers

Mesothelioma
Peritoneal mesothelioma
Pleural mesothelioma

Products

EB-MF-CAR-NK-01
Fludarabine
Cyclophosphamide

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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