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Trials
Study of MCLA-129 in Combination With Ensartinib in Patients With Advanced Solid Tumors.

trialsTrialRecruiting

Study of MCLA-129 in Combination With Ensartinib in Patients With Advanced Solid Tumors.

A phase 1/2 trial of MCLA-129 and Ensartinib in advanced solid tumours, run by Betta Pharmaceuticals Co., Ltd., now recruiting.

Overview Connected5

Overview

Study of MCLA-129 in Combination With Ensartinib in Patients With Advanced Solid Tumors. is a phase 1/2 interventional study registered as NCT07448116 by Betta Pharmaceuticals Co., Ltd., with 164 participants planned, started 2026-01-31 and due to reach its primary completion in 2029-02-01. Interventions recorded: MCLA-129 and Ensartinib.

Setting

A Multi-cohort, Open-label Phase I/II Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of the Anti-EGFR/c-Met Bispecific Antibody MCLA-129 in Combination With Ensartinib Hydrochloride in Patients With Advanced Solid Tumors.

Phase

Phase 1/2

Sponsor

Betta Pharmaceuticals Co., Ltd.

Registry

Started

2026-01-31

Enrolled

164 enrolled

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cancers

Metastatic cancer (cancer that has spread)

technologies

Small-molecule kinase inhibitors

drugs

ApprovedSmall-molecule ALK TKI (second generation)

Ensartinib · Ensacove

Phase 2bispecific antibody

companies

Betta Pharmaceuticals

Evidence strength24/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
164 enrolled+11
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT07448116

Data

JSON ·

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Cancers

Metastatic cancer (cancer that has spread)

Technologies

Small-molecule kinase inhibitors

Products

MCLA-129
Ensartinib

Companies

Betta Pharmaceuticals

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

Machine-readable versions of Study of MCLA-129 in Combination With Ensartinib in Patients With Advanced Solid Tumors.

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