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Death of brain tissue months to years after radiosurgery or high-dose brain radiotherapy, which can look exactly like tumour growing back on a scan.
Radiation necrosis affects a minority of patients after stereotactic radiosurgery to brain metastases and after high-dose treatment of gliomas, more often with larger volumes and with concurrent immunotherapy or targeted drugs. It causes swelling and symptoms that mimic progression; perfusion MRI, amino-acid PET and sometimes biopsy separate the two. Treatment is steroids, bevacizumab for refractory cases, and occasionally surgery or laser ablation.
Backbone ribbon from PDB 1BJ1. RCSB PDB 1BJ1. The ribbon widens where the chain is folded into a regular pattern and narrows where it is a loose loop.
Showing the molecule this term concerns: Bevacizumab.
Shares Gamma Knife and the tag radiation-wave1.
Shares Glioma & glioblastoma and the tag radiation-wave1.
Shares Brain and spinal cord tumours (all types) and the tag radiation-wave1.
Shares Metastatic cancer (cancer that has spread) and the tag radiation-wave1.
Shares Glioma & glioblastoma and the tag radiation-wave1.
Shares Glioma & glioblastoma and the tag radiation-wave1.
Shares Laser interstitial thermal therapy systems (NeuroBlate, Visualase), MRI, Glioma & glioblastoma.
Shares Laser interstitial thermal therapy systems (NeuroBlate, Visualase), Glioma & glioblastoma.