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Treating every visible metastasis with ablative doses when there are only a few, on the idea that some patients with limited spread can still be controlled or cured.
The oligometastatic hypothesis, proposed in 1995, holds that some cancers spread to a handful of sites before becoming widespread, and that ablating those sites can change the course of the disease. The SABR-COMET randomised phase 2 trial reported in 2019 that stereotactic treatment of one to five metastases lengthened survival compared with standard care, with some added toxicity. Phase 3 trials (SABR-COMET-3 and -10, NRG-BR002 in breast cancer, and prostate-specific studies) are now testing the approach cancer by cancer, and it has become common practice in prostate, lung and kidney cancer with limited spread.
Ablative doses to every detectable metastasis, combined with systemic therapy, aim to eliminate the visible disease rather than merely palliate it.
Query for this technology: (TITLE:"Stereotactic ablative radiotherapy for oligometastatic disease" OR ABSTRACT:"Stereotactic ablative radiotherapy for oligometastatic disease") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Stereotactic ablative radiotherapy for oligometastatic disease, not a curated reading list.
Shares CyberKnife robotic radiosurgery, SBRT / SABR (stereotactic radiotherapy), Prostate cancer and the tag radiation-wave1.
Shares CyberKnife robotic radiosurgery, SBRT / SABR (stereotactic radiotherapy), Non-small-cell lung cancer and the tag radiation-wave1.
Shares Metastatic cancer (cancer that has spread) and the tag radiation-wave1.
Shares Prostate cancer and the tag radiation-wave1.
Shares CyberKnife robotic radiosurgery, SBRT / SABR (stereotactic radiotherapy), Metastatic cancer (cancer that has spread) and the tag radiation-wave1.
Shares Prostate cancer and the tag radiation-wave1.
Shares SBRT / SABR (stereotactic radiotherapy) and the tag radiation-wave1.
Shares Non-small-cell lung cancer and the tag radiation-wave1.