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Delivering chemotherapy directly into the abdominal cavity through a catheter, so the tumour deposits on the lining get a far higher dose than the rest of the body would tolerate.
Intraperitoneal cisplatin and paclitaxel after optimal debulking improved survival in ovarian cancer in GOG-172 (2006) but toxicity and catheter problems limited uptake, and GOG-252 (with bevacizumab) showed no advantage, so HIPEC given once at surgery has largely replaced repeated IP cycles. In gastric cancer with peritoneal metastases, intraperitoneal paclitaxel with systemic chemotherapy (PHOENIX-GC, Japanese phase 3) showed borderline benefit and is used in Japan; PIPAC is the laparoscopic aerosol version. Regional chemotherapy in general (hepatic arterial infusion, isolated limb perfusion, intravesical, intrathecal) shares the same rationale of concentrating dose where the cancer is.
Showing the technology this term belongs to: HIPEC / PIPAC (intraperitoneal chemotherapy).
Shares HIPEC / PIPAC (intraperitoneal chemotherapy), Gastric & gastro-oesophageal junction cancer, Ovarian cancer.
Shares HIPEC (hyperthermic intraperitoneal chemotherapy), Peritoneum and peritoneal metastases, Debulking (cytoreductive surgery), HIPEC / PIPAC (intraperitoneal chemotherapy).
Shares HIPEC / PIPAC (intraperitoneal chemotherapy), Ovarian cancer.
Shares HIPEC / PIPAC (intraperitoneal chemotherapy), Ovarian cancer.
Shares HIPEC / PIPAC (intraperitoneal chemotherapy), Ovarian cancer.
Shares Debulking (cytoreductive surgery), HIPEC / PIPAC (intraperitoneal chemotherapy).
Shares Debulking (cytoreductive surgery), HIPEC / PIPAC (intraperitoneal chemotherapy).
Shares HIPEC (hyperthermic intraperitoneal chemotherapy), HIPEC / PIPAC (intraperitoneal chemotherapy), Gastric & gastro-oesophageal junction cancer, Ovarian cancer.