# Intraperitoneal (IP) chemotherapy

Source: https://onco.cc/terms/intraperitoneal-chemotherapy/  
OnCo record `intraperitoneal-chemotherapy` (Term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Delivering chemotherapy directly into the abdominal cavity through a catheter, so the tumour deposits on the lining get a far higher dose than the rest of the body would tolerate.

## Summary

Intraperitoneal cisplatin and paclitaxel after optimal debulking improved survival in ovarian cancer in GOG-172 (2006) but toxicity and catheter problems limited uptake, and GOG-252 (with bevacizumab) showed no advantage, so HIPEC given once at surgery has largely replaced repeated IP cycles. In gastric cancer with peritoneal metastases, intraperitoneal paclitaxel with systemic chemotherapy (PHOENIX-GC, Japanese phase 3) showed borderline benefit and is used in Japan; PIPAC is the laparoscopic aerosol version. Regional chemotherapy in general (hepatic arterial infusion, isolated limb perfusion, intravesical, intrathecal) shares the same rationale of concentrating dose where the cancer is.

## Fields

- Kind: Term
- Last checked: 2026-09-09
- Also known as: intraperitoneal; intraperitoneal chemotherapy; IP chemotherapy; IP/IV; intraperitoneal paclitaxel; intraperitoneal cisplatin; IP catheter; regional chemotherapy; locoregional chemotherapy

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Intraperitoneal_chemotherapy
- Wikipedia: https://en.wikipedia.org/wiki/Intraperitoneal_chemotherapy

## Connected records

- terms: [Debulking (cytoreductive surgery)](https://onco.cc/terms/debulking/), [HIPEC (hyperthermic intraperitoneal chemotherapy)](https://onco.cc/terms/hipec-procedure/), [Liver-directed therapy (TACE, TARE, HAI, ablation)](https://onco.cc/terms/liver-directed-therapy/), [Peritoneum and peritoneal metastases](https://onco.cc/terms/peritoneum/)
- cancers: [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Ovarian cancer](https://onco.cc/cancers/ovarian/)
- fronts: [Chemotherapy](https://onco.cc/fronts/chemotherapy/)
- technologies: [HIPEC / PIPAC (intraperitoneal chemotherapy)](https://onco.cc/technologies/hipec/), [Isolated limb perfusion and infusion](https://onco.cc/technologies/isolated-limb-perfusion/)

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