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After surgeons remove all visible tumour from the abdominal lining, the abdomen is bathed for 60-90 minutes in heated chemotherapy to kill the microscopic cells left behind.
Cytoreductive surgery plus HIPEC is standard for pseudomyxoma peritonei and appendiceal cancers and has randomised support in ovarian cancer (van Driel 2018, OVHIPEC-1) and gastric cancer prevention of peritoneal recurrence, but PRODIGE 7 showed no benefit of oxaliplatin HIPEC in colorectal peritoneal metastases, so its role there rests on complete cytoreduction alone. Heat (41-43°C) increases drug penetration to a few millimetres. PIPAC delivers aerosolised chemotherapy laparoscopically for unresectable peritoneal disease and is in trials.
Showing the technology this term belongs to: HIPEC / PIPAC (intraperitoneal chemotherapy).
Shares HIPEC perfusion pumps and PIPAC nebulisers, HIPEC / PIPAC (intraperitoneal chemotherapy), Gastric & gastro-oesophageal junction cancer, Ovarian cancer.
Shares Goblet cell adenocarcinoma of the appendix, Low-grade appendiceal mucinous neoplasm and pseudomyxoma peritonei, Appendiceal adenocarcinoma (mucinous and non-mucinous, including signet ring cell).
Shares HIPEC perfusion pumps and PIPAC nebulisers, HIPEC / PIPAC (intraperitoneal chemotherapy), Ovarian cancer, Colorectal cancer.
Shares Goblet cell adenocarcinoma of the appendix, Low-grade appendiceal mucinous neoplasm and pseudomyxoma peritonei, HIPEC perfusion pumps and PIPAC nebulisers, Appendiceal adenocarcinoma (mucinous and non-mucinous, including signet ring cell).
Shares Goblet cell adenocarcinoma of the appendix, Low-grade appendiceal mucinous neoplasm and pseudomyxoma peritonei, Appendiceal adenocarcinoma (mucinous and non-mucinous, including signet ring cell), HIPEC / PIPAC (intraperitoneal chemotherapy).
Shares Debulking (cytoreductive surgery), HIPEC perfusion pumps and PIPAC nebulisers, HIPEC / PIPAC (intraperitoneal chemotherapy), Colorectal cancer.
Shares Low-grade appendiceal mucinous neoplasm and pseudomyxoma peritonei, Appendiceal adenocarcinoma (mucinous and non-mucinous, including signet ring cell).
Shares Debulking (cytoreductive surgery), HIPEC perfusion pumps and PIPAC nebulisers, HIPEC / PIPAC (intraperitoneal chemotherapy), Colorectal cancer.