{"entity":{"id":"hipec-procedure","kind":"term","name":"HIPEC (hyperthermic intraperitoneal chemotherapy)","aka":["hyperthermic intraperitoneal chemotherapy","heated intraperitoneal chemotherapy","PIPAC","pressurised intraperitoneal aerosol chemotherapy"],"tldr":"After surgeons remove all visible tumour from the abdominal lining, the abdomen is bathed for 60-90 minutes in heated chemotherapy to kill the microscopic cells left behind.","summary":"Cytoreductive surgery plus HIPEC is standard for pseudomyxoma peritonei and appendiceal cancers and has randomised support in ovarian cancer (van Driel 2018, OVHIPEC-1) and gastric cancer prevention of peritoneal recurrence, but PRODIGE 7 showed no benefit of oxaliplatin HIPEC in colorectal peritoneal metastases, so its role there rests on complete cytoreduction alone. Heat (41-43°C) increases drug penetration to a few millimetres. PIPAC delivers aerosolised chemotherapy laparoscopically for unresectable peritoneal disease and is in trials.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Hyperthermic_intraperitoneal_chemotherapy","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Hyperthermic_intraperitoneal_chemotherapy"}],"tags":[],"related":["debulking","peritoneum","intraperitoneal-chemotherapy"],"cancers":["ovarian","colorectal","gastric"],"sections":["surgery","chemotherapy"],"technologies":["hipec"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Procedures"},"route":"/terms/hipec-procedure/","neighbours":{"term":[{"id":"debulking","kind":"term","name":"Debulking (cytoreductive surgery)","route":"/terms/debulking/"},{"id":"intraperitoneal-chemotherapy","kind":"term","name":"Intraperitoneal (IP) chemotherapy","route":"/terms/intraperitoneal-chemotherapy/"},{"id":"peritoneum","kind":"term","name":"Peritoneum and peritoneal metastases","route":"/terms/peritoneum/"}],"cancer":[{"id":"appendiceal-adenocarcinoma","kind":"cancer","name":"Appendiceal adenocarcinoma (mucinous and non-mucinous, including signet ring cell)","route":"/cancers/appendiceal-adenocarcinoma/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"goblet-cell-adenocarcinoma","kind":"cancer","name":"Goblet cell adenocarcinoma of the appendix","route":"/cancers/goblet-cell-adenocarcinoma/"},{"id":"low-grade-appendiceal-mucinous-neoplasm","kind":"cancer","name":"Low-grade appendiceal mucinous neoplasm and pseudomyxoma peritonei","route":"/cancers/low-grade-appendiceal-mucinous-neoplasm/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}],"section":[{"id":"chemotherapy","kind":"section","name":"Chemotherapy","route":"/fronts/chemotherapy/"},{"id":"surgery","kind":"section","name":"Surgery & Interventional","route":"/fronts/surgery/"}],"technology":[{"id":"hipec","kind":"technology","name":"HIPEC / PIPAC (intraperitoneal chemotherapy)","route":"/technologies/hipec/"},{"id":"hipec-pipac-devices","kind":"technology","name":"HIPEC perfusion pumps and PIPAC nebulisers","route":"/technologies/hipec-pipac-devices/"}]}}