{"entity":{"id":"intraperitoneal-chemotherapy","kind":"term","name":"Intraperitoneal (IP) chemotherapy","aka":["intraperitoneal","intraperitoneal chemotherapy","IP chemotherapy","IP/IV","intraperitoneal paclitaxel","intraperitoneal cisplatin","IP catheter","regional chemotherapy","locoregional chemotherapy"],"tldr":"Delivering chemotherapy directly into the abdominal cavity through a catheter, so the tumour deposits on the lining get a far higher dose than the rest of the body would tolerate.","summary":"Intraperitoneal cisplatin and paclitaxel after optimal debulking improved survival in ovarian cancer in GOG-172 (2006) but toxicity and catheter problems limited uptake, and GOG-252 (with bevacizumab) showed no advantage, so HIPEC given once at surgery has largely replaced repeated IP cycles. In gastric cancer with peritoneal metastases, intraperitoneal paclitaxel with systemic chemotherapy (PHOENIX-GC, Japanese phase 3) showed borderline benefit and is used in Japan; PIPAC is the laparoscopic aerosol version. Regional chemotherapy in general (hepatic arterial infusion, isolated limb perfusion, intravesical, intrathecal) shares the same rationale of concentrating dose where the cancer is.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Intraperitoneal_chemotherapy","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Intraperitoneal_chemotherapy"}],"tags":[],"related":["hipec-procedure","peritoneum","debulking","liver-directed-therapy"],"cancers":["ovarian","gastric"],"sections":["chemotherapy"],"technologies":["hipec","isolated-limb-perfusion"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Treatment jargon"},"route":"/terms/intraperitoneal-chemotherapy/","neighbours":{"term":[{"id":"debulking","kind":"term","name":"Debulking (cytoreductive surgery)","route":"/terms/debulking/"},{"id":"hipec-procedure","kind":"term","name":"HIPEC (hyperthermic intraperitoneal chemotherapy)","route":"/terms/hipec-procedure/"},{"id":"liver-directed-therapy","kind":"term","name":"Liver-directed therapy (TACE, TARE, HAI, ablation)","route":"/terms/liver-directed-therapy/"},{"id":"peritoneum","kind":"term","name":"Peritoneum and peritoneal metastases","route":"/terms/peritoneum/"}],"cancer":[{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}],"section":[{"id":"chemotherapy","kind":"section","name":"Chemotherapy","route":"/fronts/chemotherapy/"}],"technology":[{"id":"hipec","kind":"technology","name":"HIPEC / PIPAC (intraperitoneal chemotherapy)","route":"/technologies/hipec/"},{"id":"isolated-limb-perfusion","kind":"technology","name":"Isolated limb perfusion and infusion","route":"/technologies/isolated-limb-perfusion/"}]}}