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Where the food pipe meets the stomach. Cancers here are classed by how far above or below the junction they centre (Siewert I-III), which decides whether they are treated like oesophageal or stomach cancer.
Adenocarcinoma of the GEJ has risen sharply in Western countries with obesity and reflux (via Barrett's oesophagus). Siewert type I (mainly oesophageal) is treated with chemoradiation (CROSS) and oesophagectomy; type III (mainly gastric) with perioperative FLOT and extended gastrectomy; type II either way. Drug trials for HER2, PD-L1 and claudin 18.2 usually enrol gastric and GEJ tumours together, so the label 'gastric or GEJ adenocarcinoma' is common on approvals.
Squamous cancers sit in the upper and middle oesophagus, adenocarcinomas at the junction and in the stomach; the stomach wall also gives rise to GIST from its pacemaker cells.
Same organ: Gastric & gastro-oesophageal junction cancer, HER2-positive gastric cancer, Claudin 18.2-positive gastric cancer, PD-L1-high gastric cancer, Microsatellite-unstable (MSI-high) gastric cancer, Early gastric cancer, Oesophageal squamous cell carcinoma, Oesophageal and junctional adenocarcinoma, Gastrointestinal stromal tumour (GIST), KIT exon 11-mutant GIST, PDGFRA D842V-mutant GIST, Imatinib-resistant GIST
Showing the organ this term concerns: Oesophageal cancer.
Shares Gastrectomy, Gastric & gastro-oesophageal junction cancer.
Shares Barrett's oesophagus, Oesophageal cancer, Gastric & gastro-oesophageal junction cancer.
Shares Oesophagectomy, Oesophageal cancer.
Shares Barrett's oesophagus, Oesophageal cancer.
Shares CROSS, Oesophageal cancer.
Shares CROSS, Oesophageal cancer.
Shares Oesophagectomy, CROSS, Oesophageal cancer.
Shares Barrett's oesophagus, Oesophageal cancer.