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FLOT is the four-drug chemotherapy given before and after surgery for stomach cancer in the West; since 2025 immunotherapy is added to it.
FLOT4-AIO (2019): perioperative FLOT beat ECF/ECX (OS 50 vs 35 months). MATTERHORN added durvalumab (OS HR 0.78; FDA approval November 2025). Four cycles before and four after gastrectomy. Neutropenia, neuropathy, and diarrhoea; tolerability limits use in frail patients, where FOLFOX or CAPOX substitute.
Docetaxel stabilises microtubules; oxaliplatin crosslinks DNA; 5-FU/leucovorin inhibit thymidylate synthase.
1.Docetaxel freezes the microtubule scaffold so cells cannot divide
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| Adverse event |
|---|
| Neutropenia |
| Peripheral neuropathy |
| Diarrhoea, mucositis |
| Fatigue |
Common, including febrile neutropenia. Events listed without rates were not read from a primary source; see the label. Blank cells mean the figure was not sourced, not that it is zero.
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Query for this drug: (TITLE:"FLOT" OR ABSTRACT:"FLOT" OR TITLE:"5-FU, leucovorin, oxaliplatin, docetaxel" OR ABSTRACT:"5-FU, leucovorin, oxaliplatin, docetaxel") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FLOT (5-FU, leucovorin, oxaliplatin, docetaxel), not a curated reading list.
Shares Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer, BOLD-100 in Combination With FOLFOX for the Treatment of Advanced Solid Tumours, A Study to Determine the Effect of CT3001 in Patients With Advanced Solid Tumors, HSK42360-Na Tablets Combined With Cetuximab With or Without Chemotherapy in BRAF V600-Mutant Metastatic Colorectal Cancer.
Shares A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer, HSK42360-Na Tablets Combined With Cetuximab With or Without Chemotherapy in BRAF V600-Mutant Metastatic Colorectal Cancer, AZD0901 in Participants With Advanced Solid Tumours Expressing Claudin18.2, A Study of AK112 With or Without AK117 in Metastatic Colorectal Cancer.
Shares BOLD-100 in Combination With FOLFOX for the Treatment of Advanced Solid Tumours, A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer, A Study of HDM2017 Combination Therapy in Advanced Colorectal Cancer, A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A).
Shares A Study to Compare the Efficacy and Safety of YL201 With Standard Chemotherapy in Patients With Metastatic Pancreatic Cancer After Failure of Gemcitabine-Based, Newly Emerging Immunotherapy for Pancreatic Cancer Treatment, Stereotactic Body Radiation Therapy Followed by NALIRIFOX vs NALIRIFOX for Borderline Resectable Pancreatic Cancer, PANORAMIX : Optimizing 1st-line NALIRIFOX and Exploring Microbiota's Role in 2nd Line Pancreatic Cancer Treatment.
Shares Gastro-oesophageal junction (GEJ), Oesophageal and junctional adenocarcinoma, Oesophageal cancer, Platinum agents.
Shares Gastrectomy, Microsatellite-unstable (MSI-high) gastric cancer, PD-L1-high gastric cancer, HER2-positive gastric cancer.
Shares Microsatellite-unstable (MSI-high) gastric cancer, PD-L1-high gastric cancer, FOLFOX (5-FU, leucovorin, oxaliplatin), Oesophageal cancer.
Shares PD-L1-high gastric cancer, Oesophageal and junctional adenocarcinoma, Oesophageal cancer, Platinum agents.