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A phase 3 trial of Zoldonrasib, CAPOX, FLOT in pancreatic ductal adenocarcinoma, run by Revolution Medicines, Inc., now recruiting.
Study of Zoldonrasib + Chemo of Investigator's Choice vs Placebo + Chemo of Investigator's Choice as First-line Treatment in Metastatic KRAS G12D-mutated Pancreatic Adenocarcinoma ( RASolute 305 ) is a phase 3 interventional study registered as NCT07621718 by Revolution Medicines, Inc., with 670 participants planned, started 2026-05-22 and due to reach its primary completion in 2028-12-30. Interventions recorded: Zoldonrasib, Placebo, Oxaliplatin, Leucovorin (Calcium Folinate), 5-Fluorouracil. Conditions listed: Pancreatic Cancer, Pancreatic Cancer Metastatic, PDAC, PDAC - Pancreatic Ductal Adenocarcinoma. No results are recorded here; the registry entry is the source.
Shares Zoldonrasib, Revolution Medicines, KRAS mutation subtypes (G12C, G12D, G12V), KRAS & RAS inhibitors.
Shares Covalent chemistry for the RAS mutations that still have no drug, Off-the-shelf KRAS vaccines after pancreatic cancer surgery, Revolution Medicines, KRAS & RAS inhibitors.
Shares FLOT (5-FU, leucovorin, oxaliplatin, docetaxel), FOLFIRI (5-FU, leucovorin, irinotecan), CAPOX (capecitabine, oxaliplatin), Pancreatic cancer trials open today (registry snapshot and UK sites).
Shares FOLFIRI (5-FU, leucovorin, irinotecan), Leucovorin (folinic acid), CAPOX (capecitabine, oxaliplatin), Pancreatic cancer trials open today (registry snapshot and UK sites).
Shares FLOT (5-FU, leucovorin, oxaliplatin, docetaxel), FOLFIRI (5-FU, leucovorin, irinotecan), CAPOX (capecitabine, oxaliplatin), Pancreatic cancer trials open today (registry snapshot and UK sites).
Shares FOLFIRI (5-FU, leucovorin, irinotecan), Leucovorin (folinic acid), CAPOX (capecitabine, oxaliplatin), Pancreatic cancer trials open today (registry snapshot and UK sites).
Shares FLOT (5-FU, leucovorin, oxaliplatin, docetaxel), FOLFIRI (5-FU, leucovorin, irinotecan), CAPOX (capecitabine, oxaliplatin), Pancreatic cancer trials open today (registry snapshot and UK sites).
Shares Covalent chemistry for the RAS mutations that still have no drug, Off-the-shelf KRAS vaccines after pancreatic cancer surgery, Revolution Medicines, KRAS & RAS inhibitors.