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Leucovorin is not a cancer drug in itself: it rescues normal tissue after high-dose methotrexate and, given with fluorouracil, makes that chemotherapy work better, which is why it appears in FOLFOX, FOLFIRI and FOLFIRINOX.
Leucovorin (folinic acid, calcium folinate) is a form of folate that cells can use without the enzyme methotrexate blocks. Given after high-dose methotrexate it lets normal bone marrow and gut recover while the drug has already acted on the tumour; given with fluorouracil it increases the drug's binding to its target enzyme thymidylate synthase, an effect that underlies every fluorouracil-based bowel, stomach and pancreatic cancer regimen. Levoleucovorin is the active isomer alone at half the dose. It is a generic medicine on the WHO essential medicines list.
A reduced folate that bypasses dihydrofolate reductase, rescuing normal cells from methotrexate, and that stabilises the fluorouracil-thymidylate synthase complex to make fluorouracil more effective. Connects to Dihydrofolate reductase (DHFR) and Thymidylate synthase (TYMS).
1.Leucovorin (folinic acid) slips into a pocket on Dihydrofolate reductase (DHFR).
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Complete cytoreductive surgery with modern systemic chemotherapy gives a median survival over 40 months in selected patients with peritoneal metastases, and the heated intraperitoneal oxaliplatin adds only late complications.
The number every stage II conversation still uses. It is also the baseline against which ctDNA-guided de-escalation is judged: DYNAMIC halved chemotherapy use in exactly this group without losing recurrence-free survival.
FOLFOX after surgery for stage III colon cancer, still the standard 22 years later, and the reason every later adjuvant trial in this disease is an oxaliplatin trial.
The trial that created peritoneal surface malignancy as a speciality, and the reason patients with limited peritoneal disease are referred to designated centres; PRODIGE 7 later showed the benefit belongs to the surgery, not to the heated chemotherapy.
The start of adjuvant treatment for colon cancer. Levamisole was later dropped, but fluorouracil with folinic acid remained the backbone that oxaliplatin was added to in MOSAIC fourteen years later.
Query for this drug: (TITLE:"Leucovorin" OR ABSTRACT:"Leucovorin" OR TITLE:"folinic acid" OR ABSTRACT:"folinic acid" OR TITLE:"Wellcovorin" OR ABSTRACT:"Wellcovorin" OR TITLE:"generic" OR ABSTRACT:"generic" OR TITLE:"Leucovorin Calcium" OR ABSTRACT:"Leucovorin Calcium" OR TITLE:"Folinic acid" OR ABSTRACT:"Folinic acid") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Leucovorin (folinic acid), not a curated reading list.
Shares Evaluation of the Preliminary Efficacy and Safety of DR30206 in Combination With Standard Therapy in Patients With Gastrointestinal Cancer, A Phase 2 Study of SSGJ-707 in Metastatic Colorectal Cancer Patients, A Study of SHR-1826 for Injection in Combination With Other Antitumor Therapies in Subjects With Solid Tumors, HR070803 in Combination With Oxaliplatin, 5-fluorouracil/LV Versus GX as Adjuvant Therapy for Pancreatic Cancer and the tag generic.
Shares Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia, Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations, High-risk acute lymphoblastic leukaemia in children (high-risk B-ALL and T-ALL), Methotrexate and the tag generic.
Shares Rituximab, Rasburicase, and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Advanced B-Cell Leukemia or Lymphoma, Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia, Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations, Generic sterile injectables (the 2023 platinum shortage) and the tag generic.
Shares Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia, Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations, High-risk acute lymphoblastic leukaemia in children (high-risk B-ALL and T-ALL), Acute lymphoblastic leukaemia and the tag generic.
Shares Netherlands Cancer Institute HIPEC trial, Pressurized Intraperitoneal Aerosolized Chemotherapy With Mitomycin for the Treatment of Unresectable Appendix or Colorectal Cancer With Peritoneal Metastases,, Gastric & gastro-oesophageal junction cancer, Cytotoxic chemotherapy and the tag generic.
Shares Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations, High-risk acute lymphoblastic leukaemia in children (high-risk B-ALL and T-ALL), Cytotoxic chemotherapy and the tag generic.
Shares FLOT4-AIO, Gastric & gastro-oesophageal junction cancer, Cytotoxic chemotherapy and the tag generic.
Shares Cytotoxic chemotherapy and the tag generic.