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A phase 3 trial of Asparaginase, Cyclophosphamide, Cytarabine, Daunorubicin, Dexamethasone, Etoposide, Filgrastim, Leucovorin, Mercaptopurine, Methotrexate, Prednisone and Vincristine in Acute lymphoblastic leukaemia and Leukaemia, run by Children's Oncology Group, completed.
Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia is a phase 3 interventional study registered as NCT00557193 by Children's Oncology Group, with 218 participants recorded, started 2008-01-15 and reaching its primary completion in 2017-09-30. Interventions recorded: Asparaginase, Biospecimen Collection, Bone Marrow Biopsy, Cyclophosphamide, Cytarabine, Daunorubicin Hydrochloride, Dexamethasone, Echocardiography, Etoposide, Filgrastim, Laboratory Biomarker Analysis, Lestaurtinib, Leucovorin Calcium, Mercaptopurine, Methotrexate, Methylprednisolone, Multigated Acquisition Scan, Pegaspargase, Pharmacological Study, Prednisone, Therapeutic Hydrocortisone, Vincristine Sulfate. Conditions recorded: Acute Lymphoblastic Leukemia, Acute Undifferentiated Leukemia, Childhood T Acute Lymphoblastic Leukemia.
Linked to the drug Mercaptopurine because the registry names it among its interventions and Acute lymphoblastic leukaemia and Leukaemia among its conditions. Registry record only: no result has been read by an editor.
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
218 enrolled.
90% CI 25.98 to 45.66; Figures from the ClinicalTrials.gov results section (first posted 2018-12-10), not from a publication
Source| Endpoint | Arm | n | Value | HR (95% CI) | p | Source |
|---|---|---|---|---|---|---|
| Percent Probability for Event-free Survival (EFS) for Patients on Arm C at Dose Level 2 (DL2)primary | Arm C (Safety/Efficacy Dose Level 2) | 67 | 35.82% | - | - | link |
Shares Mercaptopurine, Daunorubicin, Asparaginase (pegaspargase, calaspargase pegol, Erwinia asparaginase), Cytarabine and the tag pipeline.
Shares Filgrastim (G-CSF), Cytarabine, Leucovorin (folinic acid), Methotrexate and the tag pipeline.
Shares Mercaptopurine, Daunorubicin, Cytarabine, Methotrexate and the tag pipeline.
Shares Daunorubicin, Cytarabine, Prednisone, Dexamethasone and the tag pipeline.
Shares Mercaptopurine, Daunorubicin, Cytarabine, Methotrexate and the tag pipeline.
Shares Mercaptopurine, Asparaginase (pegaspargase, calaspargase pegol, Erwinia asparaginase), Cytarabine, Methotrexate and the tag pipeline.
Shares Cytarabine, Methotrexate, Prednisone, Dexamethasone and the tag pipeline.
Shares Daunorubicin, Asparaginase (pegaspargase, calaspargase pegol, Erwinia asparaginase), Cytarabine, Methotrexate and the tag pipeline.