Cancers & treatments·Regimen libraryPerioperative

FLOT

Checked 2026-09-09

Resectable gastric or gastro-oesophageal junction adenocarcinoma, cT2 or higher or node-positive

One cycle

every 14 days × 4 · about 8 weeks in total

14-day cycle × 4 before and 4 after surgery (about 8 weeks)Intravenous Continuous infusion

Components

Drug	Dose	Route	Days	Note
Docetaxel Cytotoxic chemotherapy (taxane)	50 mg/m²	IV	D1
Oxaliplatin Third-generation platinum (DACH-platinum)	85 mg/m²	IV	D1
Leucovorin (folinic acid)	200 mg/m²	IV	D1	2-hour infusion before fluorouracil
Fluorouracil infusion Fluoropyrimidine antimetabolite	2,600 mg/m²	IV	D1, 2 (24 h infusion)

Cycles

4 before and 4 after surgery

14-day cycle

Emetogenicity

Moderate (30-90%)

G-CSF

Consider (10-20% FN risk)

Notes

MATTERHORN adds durvalumab 1,500 mg every 4 weeks to perioperative FLOT and continues it for 12 cycles.

Used in

Gastric & gastro-oesophageal junction cancer Oesophageal cancer

Trials

MATTERHORN

Products

FLOT (5-FU, leucovorin, oxaliplatin, docetaxel)DocetaxelOxaliplatinFluorouracil (5-FU)

Source

FLOT4-AIO, Lancet 2019

Reference doses for a typical adult from the cited protocol or label. Doses are adjusted for renal and hepatic function, age, performance status and prior toxicity, and institutional protocols vary. Verify against the current label and your local protocol before treating. Not medical advice.