Cancers & treatments·Regimen libraryFirst line

mFOLFOX6

Checked 2026-09-09

Adjuvant stage III colon (6 months) or metastatic colorectal and upper GI first line

Also called FOLFOX.

One cycle

every 14 days × 12 · about 24 weeks in total

14-day cycle × 12 (6 months adjuvant); until progression metastatic (about 24 weeks)Intravenous Continuous infusion

Components

Drug	Dose	Route	Days	Note
Oxaliplatin Third-generation platinum (DACH-platinum)	85 mg/m²	IV	D1
Leucovorin (folinic acid)	400 mg/m²	IV	D1	2-hour infusion before fluorouracil
Fluorouracil bolus Fluoropyrimidine antimetabolite	400 mg/m²	IV	D1
Fluorouracil infusion Fluoropyrimidine antimetabolite	2,400 mg/m²	IV	D1, 2 (46 h infusion)

Cycles

12 (6 months adjuvant); until progression metastatic

14-day cycle

Emetogenicity

Moderate (30-90%)

G-CSF

Not routine

Notes

Oxaliplatin neuropathy is cumulative; IDEA showed 3 months of CAPOX is non-inferior for low-risk stage III (T1-3 N1).
Bevacizumab 5 mg/kg or an anti-EGFR antibody is added on day 1 in metastatic disease by RAS/BRAF status and sidedness.

Used in

Colorectal cancer Gastric & gastro-oesophageal junction cancer Oesophageal cancer Pancreatic ductal adenocarcinoma

Trials

PARADIGM SUNLIGHT

Products

FOLFOX (5-FU, leucovorin, oxaliplatin)OxaliplatinFluorouracil (5-FU)

Source

MOSAIC, NEJM 2004 (FOLFOX4); mFOLFOX6 per NCCN Colon Cancer

Reference doses for a typical adult from the cited protocol or label. Doses are adjusted for renal and hepatic function, age, performance status and prior toxicity, and institutional protocols vary. Verify against the current label and your local protocol before treating. Not medical advice.