Cancers & treatments·Regimen libraryAdjuvant

CAPOX

Checked 2026-09-09

Adjuvant stage III colon (3 or 6 months), rectal total neoadjuvant therapy, metastatic first line

Also called XELOX.

One cycle

every 21 days × 4 · about 12 weeks in total

21-day cycle × 4 (3 months) or 8 (6 months) (about 12 weeks)IntravenousOral Daily oral course

Components

Drug	Dose	Route	Days	Note
Oxaliplatin Third-generation platinum (DACH-platinum)	130 mg/m²	IV	D1
Capecitabine	1,000 mg/m² twice daily	Oral	D1-14

Cycles

4 (3 months) or 8 (6 months)

21-day cycle

Emetogenicity

Moderate (30-90%)

G-CSF

Not routine

Notes

Capecitabine dose is often started at 850 mg/m² in older patients or with renal impairment; check creatinine clearance.
Hand-foot syndrome and diarrhoea drive dose holds; warfarin interaction is a boxed warning.

Used in

Colorectal cancer Gastric & gastro-oesophageal junction cancer Oesophageal cancer

Products

CAPOX (capecitabine, oxaliplatin)Oxaliplatin

Source

NCCN Colon Cancer; IDEA collaboration, NEJM 2018

Reference doses for a typical adult from the cited protocol or label. Doses are adjusted for renal and hepatic function, age, performance status and prior toxicity, and institutional protocols vary. Verify against the current label and your local protocol before treating. Not medical advice.