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Oesophageal cancer is two different diseases in one organ: squamous cell carcinoma (upper/mid oesophagus, tobacco and alcohol, dominant in Asia) and adenocarcinoma (lower oesophagus, reflux and obesity, dominant in the West).
ESCC is ~85% of cases worldwide, concentrated in the 'oesophageal cancer belt' from Iran to China; genetically resembles head-and-neck squamous cancer (TP53, NOTCH1, CCND1, SOX2) and responds better to chemoradiation and immunotherapy. EAC arises from Barrett's, resembles gastric adenocarcinoma (HER2 amplification in ~15-20%), and is treated on gastric-like pathways (FLOT, trastuzumab, zolbetuximab trials). Trial eligibility, PD-L1 scoring (TAP vs CPS), and surgery differ between them.
Squamous cancers sit in the upper and middle oesophagus, adenocarcinomas at the junction and in the stomach; the stomach wall also gives rise to GIST from its pacemaker cells.
Same organ: Gastric & gastro-oesophageal junction cancer, HER2-positive gastric cancer, Claudin 18.2-positive gastric cancer, PD-L1-high gastric cancer, Microsatellite-unstable (MSI-high) gastric cancer, Early gastric cancer, Oesophageal squamous cell carcinoma, Oesophageal and junctional adenocarcinoma, Gastrointestinal stromal tumour (GIST), KIT exon 11-mutant GIST, PDGFRA D842V-mutant GIST, Imatinib-resistant GIST
Showing the organ this term concerns: Oesophageal cancer.
Shares Barrett's oesophagus, Oesophageal cancer.
Shares Barrett's oesophagus, Oesophageal cancer.
Shares Barrett's oesophagus, Oesophageal cancer.
Shares Barrett's oesophagus, Oesophageal cancer.
Shares Barrett's oesophagus, Oesophageal cancer.
Shares Barrett's oesophagus, Oesophageal cancer.
Shares Barrett's oesophagus, Oesophageal cancer.