{"entity":{"id":"gej","kind":"term","name":"Gastro-oesophageal junction (GEJ)","aka":["GEJ","GOJ","gastroesophageal junction","gastro-oesophageal junction","oesophagogastric junction","junctional","Siewert","esophagogastric junction"],"tldr":"Where the food pipe meets the stomach. Cancers here are classed by how far above or below the junction they centre (Siewert I-III), which decides whether they are treated like oesophageal or stomach cancer.","summary":"Adenocarcinoma of the GEJ has risen sharply in Western countries with obesity and reflux (via Barrett's oesophagus). Siewert type I (mainly oesophageal) is treated with chemoradiation (CROSS) and oesophagectomy; type III (mainly gastric) with perioperative FLOT and extended gastrectomy; type II either way. Drug trials for HER2, PD-L1 and claudin 18.2 usually enrol gastric and GEJ tumours together, so the label 'gastric or GEJ adenocarcinoma' is common on approvals.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Gastroesophageal_junction","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Gastroesophageal_junction"}],"tags":[],"related":["barretts-esophagus","oesophagectomy","gastrectomy","flot"],"cancers":["esophageal","gastric"],"sections":["surgery"],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["cross"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Anatomy"},"route":"/terms/gej/","neighbours":{"term":[{"id":"barretts-esophagus","kind":"term","name":"Barrett's oesophagus","route":"/terms/barretts-esophagus/"},{"id":"flot-term","kind":"term","name":"FLOT regimen (perioperative chemotherapy for gastric cancer)","route":"/terms/flot-term/"},{"id":"gastrectomy","kind":"term","name":"Gastrectomy","route":"/terms/gastrectomy/"},{"id":"oesophagectomy","kind":"term","name":"Oesophagectomy","route":"/terms/oesophagectomy/"}],"drug":[{"id":"flot","kind":"drug","name":"FLOT (5-FU, leucovorin, oxaliplatin, docetaxel)","route":"/drugs/flot/"}],"cancer":[{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"}],"section":[{"id":"surgery","kind":"section","name":"Surgery & Interventional","route":"/fronts/surgery/"}],"trial":[{"id":"cross","kind":"trial","name":"CROSS","route":"/trials/cross/"}]}}