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A score of how well a damaged liver is still working, from five simple measures (bilirubin, albumin, clotting, fluid in the abdomen, confusion). Class A is well compensated, C is failing. Liver cancer trials almost all require class A.
Because hepatocellular carcinoma nearly always arises in cirrhosis, the liver's reserve determines whether a patient can survive resection, tolerate TACE or radioembolisation, or be given systemic therapy, and it competes with the cancer as a cause of death. Almost every phase 3 trial in liver cancer enrolled Child-Pugh A patients only, so evidence in class B is thin. The ALBI grade (albumin and bilirubin only) is a more objective alternative used in modern trials and in the BCLC algorithm.
Hepatocellular carcinoma grows in a cirrhotic liver and spreads first inside it and into the portal vein, so staging depends on liver function and vascular invasion as much as on size.
Same organ: Early hepatocellular carcinoma (BCLC 0 and A), Intermediate hepatocellular carcinoma (BCLC B), Advanced hepatocellular carcinoma (BCLC C), Hepatoblastoma
Showing the organ this term concerns: Hepatocellular carcinoma.
Shares Cirrhosis, BCLC staging, Advanced hepatocellular carcinoma (BCLC C), Hepatocellular carcinoma.
Shares BCLC staging, Hepatectomy (liver resection), Hepatocellular carcinoma.
Shares BCLC staging, Hepatocellular carcinoma.
Shares Advanced hepatocellular carcinoma (BCLC C), Hepatocellular carcinoma.
Shares Advanced hepatocellular carcinoma (BCLC C), Hepatocellular carcinoma.
Shares Advanced hepatocellular carcinoma (BCLC C), Hepatocellular carcinoma.
Shares Advanced hepatocellular carcinoma (BCLC C), Hepatocellular carcinoma.
Shares Advanced hepatocellular carcinoma (BCLC C), Hepatocellular carcinoma.