{"entity":{"id":"child-pugh","kind":"term","name":"Child-Pugh score","aka":["Child-Pugh","Child-Pugh A","Child-Pugh B","Child-Pugh class","Child–Pugh","ALBI","ALBI grade","liver function reserve"],"tldr":"A score of how well a damaged liver is still working, from five simple measures (bilirubin, albumin, clotting, fluid in the abdomen, confusion). Class A is well compensated, C is failing. Liver cancer trials almost all require class A.","summary":"Because hepatocellular carcinoma nearly always arises in cirrhosis, the liver's reserve determines whether a patient can survive resection, tolerate TACE or radioembolisation, or be given systemic therapy, and it competes with the cancer as a cause of death. Almost every phase 3 trial in liver cancer enrolled Child-Pugh A patients only, so evidence in class B is thin. The ALBI grade (albumin and bilirubin only) is a more objective alternative used in modern trials and in the BCLC algorithm.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Child%E2%80%93Pugh_score","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Child%E2%80%93Pugh_score"}],"tags":[],"related":["cirrhosis","bclc-staging","hepatectomy"],"cancers":["hcc"],"sections":["diagnostics"],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Pathology"},"route":"/terms/child-pugh/","neighbours":{"term":[{"id":"bclc-staging","kind":"term","name":"BCLC staging","route":"/terms/bclc-staging/"},{"id":"cirrhosis","kind":"term","name":"Cirrhosis","route":"/terms/cirrhosis/"},{"id":"hepatectomy","kind":"term","name":"Hepatectomy (liver resection)","route":"/terms/hepatectomy/"},{"id":"hepatotoxicity","kind":"term","name":"Hepatotoxicity (liver enzyme elevation)","route":"/terms/hepatotoxicity/"},{"id":"li-rads","kind":"term","name":"LI-RADS (Liver Imaging Reporting and Data System)","route":"/terms/li-rads/"},{"id":"pleural-effusion","kind":"term","name":"Malignant pleural effusion and ascites","route":"/terms/pleural-effusion/"}],"cancer":[{"id":"hcc-advanced","kind":"cancer","name":"Advanced hepatocellular carcinoma (BCLC C)","route":"/cancers/hcc-advanced/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"}],"section":[{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"}]}}