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Trials
Dual-Target GPC3/B7-H3 CAR-NK Cells for Advanced HCC

trialsTrialRecruiting

Dual-Target GPC3/B7-H3 CAR-NK Cells for Advanced HCC

A phase 1/2 trial of Fludarabine, Cyclophosphamide in hepatocellular carcinoma, run by Beijing Biotech, now recruiting.

Also called: DUET-HCC

Overview Connected4

Overview

Dual-Target GPC3/B7-H3 CAR-NK Cells for Advanced HCC is a phase 1/2 interventional study registered as NCT07500220 by Beijing Biotech, with 30 participants planned, started 2026-03-02 and due to reach its primary completion in 2027-03-14. Interventions recorded: EB-G3B7-NK dual-target CAR-NK cells, Fludarabine, Cyclophosphamide. Conditions listed: Advanced Hepatocellular Carcinoma (HCC), Metastatic Liver Cancer. No results are recorded here; the registry entry is the source.

Setting

A Phase 1/2, Open-Label, Dose-Escalation and Dose-Expansion Study of Allogeneic Dual-Target GPC3/B7-H3 (CD276) Chimeric Antigen Receptor Natural Killer Cells in Adults With Unresectable, Relapsed/Refractory, or Metastatic Hepatocellular Carcinoma

Phase

Phase 1/2

Sponsor

Beijing Biotech

Registry

Started

2026-03-02

Enrolled

30 enrolled

Connected

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cancers

Advanced hepatocellular carcinoma (BCLC C)Hepatocellular carcinoma

drugs

ApprovedAlkylating agent (oxazaphosphorine prodrug)

Cyclophosphamide · Cytoxan / Endoxan

ApprovedPurine nucleotide analogue (antimetabolite)

Fludarabine · Fludara (historic)

Evidence strength20/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
30 enrolled+7
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Add 115 registry trial acronyms from the CT.gov acronym f… · diff · file

Sources & links

ClinicalTrials.gov NCT07500220

Data

JSON ·

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Cancers

Hepatocellular carcinoma
Advanced hepatocellular carcinoma (BCLC C)

Products

Fludarabine
Cyclophosphamide

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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MCP server: npx -y onco-mcp, tools search, get_entity, list_kind, ask, context, compare. This record is get_entity or context with id nct07500220.

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