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Testing millions or billions of chemical compounds against a cancer target automatically to find starting points for new drugs.
Robotic HTS of 1-2 million compound libraries, fragment screening by NMR or crystallography, DNA-encoded libraries (X-Chem, HitGen, WuXi; billions of compounds per pool), affinity-selection mass spectrometry, and virtual screening of ultra-large make-on-demand spaces (Enamine REAL, tens of billions) supply hits; CRISPR pooled screens (Broad DepMap, Sanger) supply the targets. Automation vendors: Beckman, Hamilton, Tecan, Thermo Fisher; readouts increasingly imaging-based (cell painting).
Parallel assays in microtitre plates or barcoded pools identify binders or phenotypic modulators, followed by hit confirmation and medicinal chemistry.
DepMap is the lookup table drug hunters use to ask: which cancers would die if we blocked this gene, and how would we recognise them? It generated targets such as WRN and PRMT5-MTAP now in clinical trials, and it is public.
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Query for this technology: (TITLE:"High-throughput screening and DNA-encoded libraries" OR ABSTRACT:"High-throughput screening and DNA-encoded libraries") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about High-throughput screening and DNA-encoded libraries, not a curated reading list.
Shares Thermo Fisher Scientific, Drug discovery roadmap: screening in mice → maps of dependency → designing in silico, AI-driven drug & target discovery, PROTACs & molecular glues (targeted protein degradation) and the tag supporting.
Shares Drug discovery roadmap: screening in mice → maps of dependency → designing in silico and the tag supporting.
Shares AI-driven drug & target discovery and the tag supporting.
Shares Thermo Fisher Scientific and the tag supporting.
Shares Thermo Fisher Scientific and the tag supporting.
Shares Thermo Fisher Scientific and the tag supporting.
Shares Thermo Fisher Scientific and the tag supporting.
Shares AI-driven drug & target discovery and the tag supporting.
Open-source projects that implement or serve this technology, from OnCo's own catalogue: licence and last activity as the repository reported them on the day of the fetch. Listing is not endorsement; check the licence before reuse and the validation before clinical use.
Open-source lab automation robots with a Python protocol API, used in sequencing and screening labs.
Expert reviews of chemical probes for protein targets so researchers pick well-validated tools, from the Institute of Cancer Research and partners.