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TRIM28 (Transcription intermediary factor 1-beta) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Wilms tumour.
E3 SUMO and ubiquitin ligase that plays a pivotal role in embryonic development, genomic imprinting, and maintenance of genomic stability through repression of repetitive and retroviral elements. Also involved in DNA repair, regulation of innate immunity or cellular energy homeostasis. Acts as a scaffold for assembling transcriptional repression complexes containing methyltransferases, histone deacetylases, and chromatin remodelers.
Open Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes literature 0.99, genetic association 0.81, somatic mutation 0.23, genetic literature 0.76).
In plain words · TRIM28 (Transcription intermediary factor 1-beta) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Wilms tumour.
TRIM28 (Transcription intermediary factor 1-beta) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Wilms tumour.
E3 SUMO and ubiquitin ligase that plays a pivotal role in embryonic development, genomic imprinting, and maintenance of genomic stability through repression of repetitive and retroviral elements.
No product in this corpus aims at TRIM28 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1995. Earliest sequence paper UniProt cites for the protein: Lyle et al, 1995. Source.
Sources: HGNC HGNC:16384 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13263 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000130726 (association with cancer (MONDO_0004992) 0.70; per-cancer scores at or above 0.5: Wilms tumour 0.67 (GraphQL API, CC0))
E3 SUMO and ubiquitin ligase that plays a pivotal role in embryonic development, genomic imprinting, and maintenance of genomic stability through repression of repetitive and retroviral elements. Also involved in DNA repair, regulation of innate immunity or cellular energy homeostasis. Acts as a scaffold for assembling transcriptional repression complexes containing methyltransferases, histone deacetylases, and chromatin remodelers. Serves as a nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs), mediating gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1, which methylates histone H3 at 'Lys-9' (H3K9me), leading to heterochromatin formation. In collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway. Functions as a coactivator for CEBPB and NR3C1 (glucocorticoid receptor) in transcriptional activation of ORM1, and as a corepressor for ERBB4. Location: Nucleus (UniProt). Locus 19q13.43 (HGNC).
Query for this target: (TITLE:"TRIM28" OR ABSTRACT:"TRIM28" OR TITLE:"tripartite motif containing 28" OR ABSTRACT:"tripartite motif containing 28" OR TITLE:"Transcription intermediary factor 1-beta" OR ABSTRACT:"Transcription intermediary factor 1-beta" OR TITLE:"TIF1B" OR ABSTRACT:"TIF1B" OR TITLE:"KAP1" OR ABSTRACT:"KAP1" OR TITLE:"TF1B" OR ABSTRACT:"TF1B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TRIM28, not a curated reading list.
Shares Wilms tumour (nephroblastoma), Open Targets Platform.
Shares Wilms tumour (nephroblastoma), Open Targets Platform.
Shares Wilms tumour (nephroblastoma), Open Targets Platform.
Shares Wilms tumour (nephroblastoma), Open Targets Platform.
Shares Wilms tumour (nephroblastoma), Open Targets Platform.
Shares Wilms tumour (nephroblastoma), Open Targets Platform.