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SIX1 (Homeobox protein SIX1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer and Wilms tumour.
Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as a transcriptional repressor or activator.
Open Targets scores its association with cancer at 0.73 (direct and indirect evidence; datatypes literature 0.99, animal model 0.49, genetic association 0.51, somatic mutation 0.89). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Wilms' Tumour.
In plain words · SIX1 (Homeobox protein SIX1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer and Wilms tumour.
SIX1 (Homeobox protein SIX1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer and Wilms tumour.
Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear.
No product in this corpus aims at SIX1 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1996. Earliest sequence paper UniProt cites for the protein: Boucher C.A. et al, Genomics, 1996, "Cloning of the human SIX1 gene and its assignment to chromosome 14". Source.
Sources: HGNC HGNC:10887 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15475 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000126778 (association with cancer (MONDO_0004992) 0.73; per-cancer scores at or above 0.5: colorectal cancer 0.52 (GraphQL API, CC0)); IntOGen SIX1 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as a transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter and CIDEA enhancer. Location: Nucleus; Cytoplasm (UniProt). Locus 14q23.1 (HGNC).
Query for this target: (TITLE:"SIX1" OR ABSTRACT:"SIX1" OR TITLE:"SIX homeobox 1" OR ABSTRACT:"SIX homeobox 1" OR TITLE:"Homeobox protein SIX1" OR ABSTRACT:"Homeobox protein SIX1" OR TITLE:"DFNA23" OR ABSTRACT:"DFNA23") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SIX1, not a curated reading list.
Shares Wilms tumour (nephroblastoma), IntOGen, Open Targets Platform.
Shares Wilms tumour (nephroblastoma), Open Targets Platform.
Shares Wilms tumour (nephroblastoma), Open Targets Platform.
Shares Wilms tumour (nephroblastoma), IntOGen, Open Targets Platform.
Shares Wilms tumour (nephroblastoma), IntOGen, Open Targets Platform, Colorectal cancer.
Shares Wilms tumour (nephroblastoma), IntOGen.
Shares Wilms tumour (nephroblastoma), IntOGen, Open Targets Platform.