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CTR9 (RNA polymerase-associated protein CTR9 homolog) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Wilms tumour.
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.57, genetic literature 0.74).
In plain words · CTR9 (RNA polymerase-associated protein CTR9 homolog) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Wilms tumour.
CTR9 (RNA polymerase-associated protein CTR9 homolog) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Wilms tumour.
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency.
No product in this corpus aims at CTR9 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1995. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1995, "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". Source.
Sources: HGNC HGNC:16850 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6PD62 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000198730 (association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: Wilms tumour 0.58 (GraphQL API, CC0))
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in haematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. Location: Nucleus speckle (UniProt). Locus 11p15.4 (HGNC).
Query for this target: (TITLE:"CTR9" OR ABSTRACT:"CTR9" OR TITLE:"CTR9 component of Paf1/RNA polymerase II complex" OR ABSTRACT:"CTR9 component of Paf1/RNA polymerase II complex" OR TITLE:"RNA polymerase-associated protein CTR9 homolog" OR ABSTRACT:"RNA polymerase-associated protein CTR9 homolog" OR TITLE:"KIAA0155" OR ABSTRACT:"KIAA0155" OR TITLE:"p150TSP" OR ABSTRACT:"p150TSP" OR TITLE:"SH2BP1" OR ABSTRACT:"SH2BP1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CTR9, not a curated reading list.
Shares Wilms tumour (nephroblastoma), Open Targets Platform.
Shares Wilms tumour (nephroblastoma), Open Targets Platform.
Shares Wilms tumour (nephroblastoma), Open Targets Platform.
Shares Wilms tumour (nephroblastoma), Open Targets Platform.
Shares Wilms tumour (nephroblastoma), Open Targets Platform.
Shares Wilms tumour (nephroblastoma), Open Targets Platform.