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WT1 (Wilms tumour protein) is a protein that switches other genes on and off. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Leukaemia, Mesothelioma, Myeloproliferative neoplasms and 5 more.
Transcription factor that plays an important role in cellular development and cell survival. Recognises and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO.
CIViC holds 12 clinical evidence items and 0 assertions across 3 variants, naming Daunorubicin and Cytarabine. Open Targets scores its association with cancer at 0.90 (direct and indirect evidence; datatypes clinical 0.63, genetic literature 0.90, affected pathway 0.36, literature 1.00, genetic association 0.91, somatic mutation 0.89, animal model 0.68). IntOGen calls it a driver in 4 cohorts (1 activating, 3 loss-of-function), covering Acute Myeloid Leukaemia, Melanoma, Pancreatic Adenocarcinoma. In OnCo, 1 product record names it (INO-5401).
In plain words · WT1 (Wilms tumour protein) is a protein that switches other genes on and off. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Leukaemia, Mesothelioma, Myeloproliferative neoplasms and 5 more.
WT1 (Wilms tumour protein) is a protein that switches other genes on and off. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Leukaemia, Mesothelioma, Myeloproliferative neoplasms and 5 more.
Transcription factor that plays an important role in cellular development and cell survival. Recognises and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'.
No product in this corpus aims at WT1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Tumour-associated overexpression: HPA finds the RNA cancer enriched in cancer (Ovary Serous Cystadenocarcinoma (TCGA)) and tissue enhanced in normal endometrium 1, fallopian tube, ovary, smooth muscle, so the tumour and the normal tissue it comes from share the target and the medicine relies on the difference in level. HPA WT1: RNA tissue enhanced (endometrium 1 42 nTPM, fallopian tube 49 nTPM, ovary 28 nTPM); high antibody staining in 5 normal tissues; highest cancer staining glioma (8 of 12 high). Distribution: 7 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Leukaemia, Mesothelioma, Myeloid neoplasms, Lymphoma, Sarcomas (soft tissue, bone, GIST), Pancreatic ductal adenocarcinoma, Childhood cancers (all types)); Open Targets associates it with 7 specific cancer types at or above 0.5 (Wilms tumor 1, malignant mesothelioma, Nephroblastoma, Wilms tumor, WAGR syndrome, acute myeloid leukemia and more). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas WT1 tissue; Human Protein Atlas WT1 pathology; Open Targets ENSG00000184937 associations
First described 1990. Earliest sequence paper UniProt cites for the protein: Gessler et al, Nature, 1990, "Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping". Source.
Sources: HGNC HGNC:12796 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P19544 (protein name, function text, keywords and locations (REST API)); CIViC gene WT1 (12 evidence items, 0 assertions, 3 variants; diseases: Acute Myeloid Leukaemia (GraphQL API, CC0)); Open Targets ENSG00000184937 (association with cancer (MONDO_0004992) 0.90; per-cancer scores at or above 0.5: sarcoma 0.59, malignant mesothelioma 0.69, acute myeloid leukaemia 0.65, acute lymphoblastic leukaemia 0.56, non-Hodgkin lymphoma 0.60, myeloproliferative neoplasm 0.68 (GraphQL API, CC0)); IntOGen WT1 (driver in 4 cohorts (Act 1, LoF 3); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Transcription factor that plays an important role in cellular development and cell survival. Recognises and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumour suppressor as well as an oncogenic role in tumour formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Location: Nucleus; Nucleus, nucleolus; Cytoplasm; Nucleus speckle (UniProt). Locus 11p13 (HGNC).
RNA: tissue enhanced (endometrium 1 42 nTPM, fallopian tube 49 nTPM, ovary 28 nTPM, smooth muscle 31 nTPM), detected in many normal tissues.
Medium: Ovary, Smooth muscle.
RNA cancer enriched: Ovary Serous Cystadenocarcinoma 98 pTPM.
Medium only: lung cancer, lymphoma.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"WT1" OR ABSTRACT:"WT1" OR TITLE:"WT1 transcription factor" OR ABSTRACT:"WT1 transcription factor" OR TITLE:"Wilms tumor protein" OR ABSTRACT:"Wilms tumor protein" OR TITLE:"WIT-2" OR ABSTRACT:"WIT-2" OR TITLE:"AWT1" OR ABSTRACT:"AWT1" OR TITLE:"NPHS4" OR ABSTRACT:"NPHS4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about WT1, not a curated reading list.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), CIViC, Acute myeloid leukaemia.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Sarcomas (soft tissue, bone, GIST), CIViC.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Sarcomas (soft tissue, bone, GIST), CIViC.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Sarcomas (soft tissue, bone, GIST), CIViC.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), CIViC, Acute myeloid leukaemia.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Acute myeloid leukaemia, IntOGen.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), CIViC, Acute myeloid leukaemia.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Sarcomas (soft tissue, bone, GIST), CIViC.