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INO-5401 is an experimental cancer vaccine from Inovio Pharmaceuticals in phase 2 trials for glioma & glioblastoma, aimed at PSMA.
INO-5401 is a cancer vaccine developed by Inovio Pharmaceuticals. Its target is PSMA (the sponsor names WT1, PSMA, hTERT). The sponsor states: A combination of three separate DNA plasmids targeting the Wilms tumour gene-1 (WT1) antigen, prostate-specific membrane antigen (PSMA) and human telomerase reverse transcriptase (hTERT), delivered intramuscularly followed by electroporation with the CELLECTRA device to stimulate an anti-tumour immune response. ClinicalTrials.gov describes the intervention as: INO-5401 is a combination of 3 separate DNA plasmids targeting Wilms tumour gene-1 (WT1) antigen, prostate-specific membrane antigen (PSMA) and human telomerase reverse transcriptase (hTERT) genes. Starting on Day 0 three milligrams (mg) of. It is the investigational product in 1 recruiting or active industry-led phase 2 and phase 3 interventional cancer trial, in glioma & glioblastoma. The largest, NCT03491683, plans to enrol 52 participants (actual) with primary completion expected 2026-12-31. Status reflects the highest phase registered on ClinicalTrials.gov; no efficacy results are recorded here.
A combination of three separate DNA plasmids targeting the Wilms tumour gene-1 (WT1) antigen, prostate-specific membrane antigen (PSMA) and human telomerase reverse transcriptase (hTERT), delivered intramuscularly followed by electroporation with the CELLECTRA device to stimulate an anti-tumour immune response. Connects to PSMA.
1.INO-5401 slips into a pocket on PSMA.
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Query for this drug: (TITLE:"INO-5401" OR ABSTRACT:"INO-5401") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about INO-5401, not a curated reading list.
Shares PSMA and the tag pipeline.
Shares PSMA and the tag pipeline.
Shares PSMA and the tag pipeline.
Shares PSMA and the tag pipeline.
Shares Glioma & glioblastoma and the tag pipeline.
Shares Glioma & glioblastoma and the tag pipeline.
Shares Glioma & glioblastoma and the tag pipeline.
Shares Glioma & glioblastoma and the tag pipeline.