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Trials
INO-5401 and INO-9012 Delivered by Electroporation (EP) in Combination With Cemiplimab (REGN2810) in Newly-Diagnosed Glioblastoma (GBM)

trialsTrialActive

INO-5401 and INO-9012 Delivered by Electroporation (EP) in Combination With Cemiplimab (REGN2810) in Newly-Diagnosed Glioblastoma (GBM)

A phase 1/2 trial of INO-5401, Cemiplimab and Temozolomide in glioma & glioblastoma, run by Inovio Pharmaceuticals, active and no longer recruiting.

Overview Connected6

Overview

INO-5401 and INO-9012 Delivered by Electroporation (EP) in Combination With Cemiplimab (REGN2810) in Newly-Diagnosed Glioblastoma (GBM) is a phase 1/2 interventional study registered as NCT03491683 by Inovio Pharmaceuticals, with 52 participants enrolled, started 2018-05-31 and due to reach its primary completion in 2026-12-31. Interventions recorded: INO-5401, INO-9012, Cemiplimab, Radiation Therapy and Temozolomide.

Setting

An Open-Label, Multi-Center Trial of INO-5401 and INO-9012 Delivered by Electroporation (EP) in Combination With REGN2810 in Subjects With Newly-Diagnosed Glioblastoma (GBM)

Phase

Phase 1/2

Sponsor

Inovio Pharmaceuticals

Registry

Started

2018-05-31

Enrolled

52 enrolled

Connected

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cancers

Glioma & glioblastoma

technologies

Immune checkpoint inhibitors

drugs

ApprovedMonoclonal antibody (anti-PD-1)

Cemiplimab · Libtayo

Phase 2vaccine

ApprovedOral alkylating chemotherapy

Temozolomide · Temodar

companies

Inovio Pharmaceuticals

Evidence strength22/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
52 enrolled+9
No structured primary endpoint0
Result: active0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT03491683

Data

JSON ·

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Cancers

Glioma & glioblastoma

Technologies

Immune checkpoint inhibitors

Products

INO-5401
Cemiplimab
Temozolomide

Companies

Inovio Pharmaceuticals

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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