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SAMD9L (Sterile alpha motif domain-containing protein 9-like) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Myelodysplastic syndromes / neoplasms.
May be involved in endosome fusion. Mediates down-regulation of growth factor signalling via internalisation of growth factor receptors.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.79, animal model 0.58, genetic association 0.19, genetic literature 0.76).
In plain words · SAMD9L (Sterile alpha motif domain-containing protein 9-like) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Myelodysplastic syndromes / neoplasms.
SAMD9L (Sterile alpha motif domain-containing protein 9-like) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Myelodysplastic syndromes / neoplasms.
May be involved in endosome fusion. Mediates down-regulation of growth factor signalling via internalisation of growth factor receptors.
No product in this corpus aims at SAMD9L yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2002. Earliest sequence paper UniProt cites for the protein: Nagase et al, 2002, "The nucleotide sequence of a long cDNA clone isolated from human". Source.
Sources: HGNC HGNC:1349 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8IVG5 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000177409 (association with cancer (MONDO_0004992) 0.51; per-cancer scores at or above 0.5: myelodysplastic syndrome 0.69 (GraphQL API, CC0))
May be involved in endosome fusion. Mediates down-regulation of growth factor signalling via internalisation of growth factor receptors. Location: Early endosome; Mitochondrion (UniProt). Locus 7q21.2 (HGNC).
Query for this target: (TITLE:"SAMD9L" OR ABSTRACT:"SAMD9L" OR TITLE:"sterile alpha motif domain containing 9 like" OR ABSTRACT:"sterile alpha motif domain containing 9 like" OR TITLE:"Sterile alpha motif domain-containing protein 9-like" OR ABSTRACT:"Sterile alpha motif domain-containing protein 9-like" OR TITLE:"KIAA2005" OR ABSTRACT:"KIAA2005" OR TITLE:"FLJ39885" OR ABSTRACT:"FLJ39885" OR TITLE:"C7orf6" OR ABSTRACT:"C7orf6") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SAMD9L, not a curated reading list.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.