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MT-CO1 (Cytochrome c oxidase subunit 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Myelodysplastic syndromes / neoplasms and Colorectal cancer.
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyses the reduction of oxygen to water.
Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.38, genetic association 0.74, genetic literature 0.30).
In plain words · MT-CO1 (Cytochrome c oxidase subunit 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Myelodysplastic syndromes / neoplasms and Colorectal cancer.
MT-CO1 (Cytochrome c oxidase subunit 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Myelodysplastic syndromes / neoplasms and Colorectal cancer.
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
No product in this corpus aims at MT-CO1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1980. Earliest sequence paper UniProt cites for the protein: Sanger et al, J. Mol. Biol, 1980, "Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing". Source.
Sources: HGNC HGNC:7419 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P00395 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000198804 (association with cancer (MONDO_0004992) 0.50; per-cancer scores at or above 0.5: colorectal cancer 0.50, myelodysplastic syndrome 0.64 (GraphQL API, CC0))
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyses the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A centre (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear centre (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Location: Mitochondrion inner membrane (UniProt). Locus mitochondria (HGNC).
Query for this target: (TITLE:"MT-CO1" OR ABSTRACT:"MT-CO1" OR TITLE:"mitochondrially encoded cytochrome c oxidase I" OR ABSTRACT:"mitochondrially encoded cytochrome c oxidase I" OR TITLE:"Cytochrome c oxidase subunit 1" OR ABSTRACT:"Cytochrome c oxidase subunit 1" OR TITLE:"COX1" OR ABSTRACT:"COX1" OR TITLE:"MTCO1" OR ABSTRACT:"MTCO1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MT-CO1, not a curated reading list.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.