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SAMD9 (Sterile alpha motif domain-containing protein 9) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Myelodysplastic syndromes / neoplasms.
Double-stranded nucleic acid binding that acts as an antiviral factor by playing an essential role in the formation of cytoplasmic antiviral granules. May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF signalling. Involved in the regulation of EGR1, in coordination with RGL2.
In plain words · SAMD9 (Sterile alpha motif domain-containing protein 9) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Myelodysplastic syndromes / neoplasms.
SAMD9 (Sterile alpha motif domain-containing protein 9) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Myelodysplastic syndromes / neoplasms.
Double-stranded nucleic acid binding that acts as an antiviral factor by playing an essential role in the formation of cytoplasmic antiviral granules.
No product in this corpus aims at SAMD9 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2002. Earliest sequence paper UniProt cites for the protein: Nagase et al, 2002, "The nucleotide sequence of a long cDNA clone isolated from human". Source.
Sources: HGNC HGNC:1348 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q5K651 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000205413 (per-cancer scores at or above 0.5: myelodysplastic syndrome 0.66 (GraphQL API, CC0))
Double-stranded nucleic acid binding that acts as an antiviral factor by playing an essential role in the formation of cytoplasmic antiviral granules. May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF signalling. Involved in the regulation of EGR1, in coordination with RGL2. May be involved in endosome fusion. Location: Cytoplasm (UniProt). Locus 7q21.2 (HGNC).
Query for this target: (TITLE:"SAMD9" OR ABSTRACT:"SAMD9" OR TITLE:"sterile alpha motif domain containing 9" OR ABSTRACT:"sterile alpha motif domain containing 9" OR TITLE:"Sterile alpha motif domain-containing protein 9" OR ABSTRACT:"Sterile alpha motif domain-containing protein 9" OR TITLE:"KIAA2004" OR ABSTRACT:"KIAA2004" OR TITLE:"FLJ20073" OR ABSTRACT:"FLJ20073" OR TITLE:"C7orf5" OR ABSTRACT:"C7orf5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SAMD9, not a curated reading list.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.