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MYSM1 (Deubiquitinase MYSM1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Myelodysplastic syndromes / neoplasms.
Metalloprotease with deubiquitinase activity that plays important regulator roles in haematopoietic stem cell function, blood cell production and immune response. Participates in the normal programming of B-cell responses to antigen after the maturation process. Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity.
In plain words · MYSM1 (Deubiquitinase MYSM1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Myelodysplastic syndromes / neoplasms.
MYSM1 (Deubiquitinase MYSM1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Myelodysplastic syndromes / neoplasms.
Metalloprotease with deubiquitinase activity that plays important regulator roles in haematopoietic stem cell function, blood cell production and immune response.
No product in this corpus aims at MYSM1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 2001. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2001, "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". Source.
Sources: HGNC HGNC:29401 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q5VVJ2 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000162601 (per-cancer scores at or above 0.5: myelodysplastic syndrome 0.56 (GraphQL API, CC0))
Metalloprotease with deubiquitinase activity that plays important regulator roles in haematopoietic stem cell function, blood cell production and immune response. Participates in the normal programming of B-cell responses to antigen after the maturation process. Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity. Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes. Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component. Suppresses the CGAS-STING1 signalling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains. Location: Nucleus; Cytoplasm (UniProt). Locus 1p32.1 (HGNC).
Query for this target: (TITLE:"MYSM1" OR ABSTRACT:"MYSM1" OR TITLE:"Myb like, SWIRM and MPN domains 1" OR ABSTRACT:"Myb like, SWIRM and MPN domains 1" OR TITLE:"Deubiquitinase MYSM1" OR ABSTRACT:"Deubiquitinase MYSM1" OR TITLE:"KIAA1915" OR ABSTRACT:"KIAA1915") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MYSM1, not a curated reading list.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.
Shares Myelodysplastic syndromes / neoplasms (MDS), Open Targets Platform.