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MAX (MYC associated transcriptional regulator X) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Neuroendocrine tumours, Multiple myeloma, Endometrial cancer and 5 more.
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognises the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor.
Open Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.89, genetic association 0.17, somatic mutation 0.95). IntOGen calls it a driver in 10 cohorts (7 activating, 3 loss-of-function), covering Invasive Breast Carcinoma, Gastrointestinal Stromal Tumour, Low-Grade Glioma, NOS, Medulloblastoma, Pilocytic Astrocytoma, Plasma Cell Myeloma and others.
In plain words · MAX (MYC associated transcriptional regulator X) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Neuroendocrine tumours, Multiple myeloma, Endometrial cancer and 5 more.
MAX (MYC associated transcriptional regulator X) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Neuroendocrine tumours, Multiple myeloma, Endometrial cancer and 5 more.
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognises the core sequence 5'-CAC[GA]TG-3'.
No product in this corpus aims at MAX yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1991. Earliest sequence paper UniProt cites for the protein: Blackwood E.M. et al, Science, 1991, "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc". Source.
Sources: HGNC HGNC:6913 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P61244 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000125952 (association with cancer (MONDO_0004992) 0.74; per-cancer scores at or above 0.5: colorectal cancer 0.53, melanoma 0.52, neuroendocrine neoplasm 0.76, plasma cell myeloma 0.51, skin cancer 0.53, breast cancer 0.55 (GraphQL API, CC0)); IntOGen MAX (driver in 10 cohorts (Act 7, LoF 3); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognises the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. Location: Nucleus; Cell projection, dendrite (UniProt). Locus 14q23.3 (HGNC).
Query for this target: (TITLE:"MAX" OR ABSTRACT:"MAX" OR TITLE:"MYC associated transcriptional regulator X" OR ABSTRACT:"MYC associated transcriptional regulator X" OR TITLE:"bHLHd4" OR ABSTRACT:"bHLHd4" OR TITLE:"bHLHd5" OR ABSTRACT:"bHLHd5" OR TITLE:"bHLHd6" OR ABSTRACT:"bHLHd6" OR TITLE:"bHLHd7" OR ABSTRACT:"bHLHd7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MAX, not a curated reading list.
Shares Gastrointestinal stromal tumour (GIST), Neuroendocrine tumours, Breast cancer (all types), Open Targets Platform.
Shares Small intestine cancer (small bowel adenocarcinoma), Neuroendocrine tumours, IntOGen, Multiple myeloma.
Shares Gastrointestinal stromal tumour (GIST), Neuroendocrine tumours, IntOGen, Open Targets Platform.
Shares Gastrointestinal stromal tumour (GIST), Neuroendocrine tumours, Breast cancer (all types), Open Targets Platform.
Shares Small intestine cancer (small bowel adenocarcinoma), IntOGen.
Shares Small intestine cancer (small bowel adenocarcinoma), Gastrointestinal stromal tumour (GIST), Colorectal cancer.
Shares Small intestine cancer (small bowel adenocarcinoma), IntOGen, Breast cancer (all types).
Shares Small intestine cancer (small bowel adenocarcinoma), IntOGen, Open Targets Platform.