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SNX29 (Sorting nexin-29) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer and Small intestine cancer.
UniProt has no function text for Q8TEQ0; HGNC names it "sorting nexin 29".
IntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Bladder Urothelial Carcinoma, Small Intestinal Carcinoma.
In plain words · SNX29 (Sorting nexin-29) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer and Small intestine cancer.
SNX29 (Sorting nexin-29) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer and Small intestine cancer.
UniProt has no function text for Q8TEQ0; HGNC names it "sorting nexin 29". Locus 16p13.13-p13.12 (HGNC).
No product in this corpus aims at SNX29 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 2003. Earliest sequence paper UniProt cites for the protein: Jikuya et al, DNA Res, 2003, "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones". Source.
Sources: HGNC HGNC:30542 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8TEQ0 (protein name, function text, keywords and locations (REST API)); IntOGen SNX29 (driver in 2 cohorts (Act 1, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
UniProt has no function text for Q8TEQ0; HGNC names it "sorting nexin 29". Locus 16p13.13-p13.12 (HGNC).
Query for this target: (TITLE:"SNX29" OR ABSTRACT:"SNX29" OR TITLE:"sorting nexin 29" OR ABSTRACT:"sorting nexin 29" OR TITLE:"Sorting nexin-29" OR ABSTRACT:"Sorting nexin-29" OR TITLE:"FLJ12363" OR ABSTRACT:"FLJ12363" OR TITLE:"RUNDC2A" OR ABSTRACT:"RUNDC2A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SNX29, not a curated reading list.
Shares Small intestine cancer (small bowel adenocarcinoma), IntOGen.
Shares Small intestine cancer (small bowel adenocarcinoma), IntOGen.
Shares Small intestine cancer (small bowel adenocarcinoma), IntOGen.
Shares Small intestine cancer (small bowel adenocarcinoma), IntOGen.