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SDHC (Succinate dehydrogenase cytochrome b560 subunit, mitochondrial) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours, Breast cancer, Colorectal cancer and 1 more.
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidises malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerised into keto-oxaloacetate.
Open Targets scores its association with cancer at 0.75 (direct and indirect evidence; datatypes genetic literature 0.79, literature 0.91, genetic association 0.43, somatic mutation 0.97, animal model 0.38).
In plain words · SDHC (Succinate dehydrogenase cytochrome b560 subunit, mitochondrial) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours, Breast cancer, Colorectal cancer and 1 more.
SDHC (Succinate dehydrogenase cytochrome b560 subunit, mitochondrial) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours, Breast cancer, Colorectal cancer and 1 more.
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
No product in this corpus aims at SDHC yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1996. Earliest sequence paper UniProt cites for the protein: Au H.C. et al, 1996, "The cDNA sequence of human CII-3, an integral membrane protein subunit of complex II of the mitochondria electron transport chain". Source.
Sources: HGNC HGNC:10682 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q99643 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000143252 (association with cancer (MONDO_0004992) 0.75; per-cancer scores at or above 0.5: colorectal cancer 0.50, neuroendocrine neoplasm 0.83, gastrointestinal stromal tumour 0.72, breast cancer 0.54 (GraphQL API, CC0))
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidises malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerised into keto-oxaloacetate. Location: Mitochondrion inner membrane (UniProt). Locus 1q23.3 (HGNC).
Query for this target: (TITLE:"SDHC" OR ABSTRACT:"SDHC" OR TITLE:"succinate dehydrogenase complex subunit C" OR ABSTRACT:"succinate dehydrogenase complex subunit C" OR TITLE:"Succinate dehydrogenase cytochrome b560 subunit, mitochondrial" OR ABSTRACT:"Succinate dehydrogenase cytochrome b560 subunit, mitochondrial" OR TITLE:"CYB560" OR ABSTRACT:"CYB560" OR TITLE:"cybL" OR ABSTRACT:"cybL" OR TITLE:"PGL3" OR ABSTRACT:"PGL3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SDHC, not a curated reading list.
Shares Gastrointestinal stromal tumour (GIST), Neuroendocrine tumours, Breast cancer (all types), Open Targets Platform.
Shares Gastrointestinal stromal tumour (GIST), Neuroendocrine tumours, Breast cancer (all types), Open Targets Platform.
Shares Gastrointestinal stromal tumour (GIST), Neuroendocrine tumours, Open Targets Platform, Colorectal cancer.
Shares Gastrointestinal stromal tumour (GIST), Open Targets Platform.
Shares Gastrointestinal stromal tumour (GIST), Colorectal cancer.
Shares Gastrointestinal stromal tumour (GIST), Neuroendocrine tumours, Colorectal cancer.