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SDHC (Succinate dehydrogenase cytochrome b560 subunit, mitochondrial) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours, Breast cancer, Colorectal cancer and 1 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidises malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerised into keto-oxaloacetate. Location: Mitochondrion inner membrane (UniProt). Locus 1q23.3 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"SDHC" OR ABSTRACT:"SDHC" OR TITLE:"succinate dehydrogenase complex subunit C" OR ABSTRACT:"succinate dehydrogenase complex subunit C" OR TITLE:"Succinate dehydrogenase cytochrome b560 subunit, mitochondrial" OR ABSTRACT:"Succinate dehydrogenase cytochrome b560 subunit, mitochondrial" OR TITLE:"CYB560" OR ABSTRACT:"CYB560" OR TITLE:"cybL" OR ABSTRACT:"cybL" OR TITLE:"PGL3" OR ABSTRACT:"PGL3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SDHC, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/sdhc.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/sdhc.json. Licence CC BY-NC 4.0.